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    Chrm1 cholinergic receptor, muscarinic 1, CNS [ Mus musculus (house mouse) ]

    Gene ID: 12669, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrm1provided by MGI
    Official Full Name
    cholinergic receptor, muscarinic 1, CNSprovided by MGI
    Primary source
    MGI:MGI:88396
    See related
    Ensembl:ENSMUSG00000032773 AllianceGenome:MGI:88396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M1; M1R; Chrm-1
    Summary
    Predicted to enable G protein-coupled acetylcholine receptor activity. Involved in postsynaptic modulation of chemical synaptic transmission and regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Is active in Schaffer collateral - CA1 synapse; cholinergic synapse; and postsynaptic membrane. Is expressed in central nervous system; exocrine system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 19.3), frontal lobe adult (RPKM 14.8) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chrm1 in Genome Data Viewer
    Location:
    19 A; 19 5.44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8641369..8660970)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8664005..8683606)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36394 Neighboring gene solute carrier family 22 (organic anion transporter), member 6 Neighboring gene RIKEN cDNA 9830166K06 gene Neighboring gene STARR-positive B cell enhancer ABC_E8737 Neighboring gene STARR-positive B cell enhancer ABC_E9454 Neighboring gene solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1210 Neighboring gene predicted gene, 25855 Neighboring gene small nucleolar RNA host gene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway  
    involved_in G protein-coupled acetylcholine receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  
    involved_in chemical synaptic transmission  
    involved_in cognition  
    involved_in neuromuscular synaptic transmission  
    involved_in neuromuscular synaptic transmission  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of intracellular protein transport  
    acts_upstream_of_or_within positive regulation of monoatomic ion transport PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within regulation of locomotion PubMed 
    involved_in regulation of postsynaptic membrane potential PubMed 
    involved_in regulation of postsynaptic membrane potential PubMed 
    involved_in regulation of postsynaptic membrane potential PubMed 
    involved_in saliva secretion  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in asymmetric synapse  
    located_in axon terminus  
    located_in axon terminus  
    is_active_in cholinergic synapse PubMed 
    is_active_in dendrite  
    located_in dendrite  
    located_in dendrite  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in plasma membrane  
    located_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic membrane PubMed 
    located_in presynaptic membrane  
    is_active_in presynaptic membrane  
    is_active_in synapse  

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M1
    Names
    AChR M1
    m1 muscarinic acetylcholine receptor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112697.1NP_001106167.1  muscarinic acetylcholine receptor M1

      See identical proteins and their annotated locations for NP_001106167.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC025794, AK138282, AW495047, BB848456, BC094242, BY062993
      Consensus CDS
      CCDS29539.1
      UniProtKB/Swiss-Prot
      P12657, Q52KQ0, Q8BJN3
      Related
      ENSMUSP00000126103.2, ENSMUST00000163785.2
      Conserved Domains (1) summary
      cd17790
      Location:26429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_007698.3NP_031724.2  muscarinic acetylcholine receptor M1

      See identical proteins and their annotated locations for NP_031724.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC025794, AK138282, AW495047, BC094242
      Consensus CDS
      CCDS29539.1
      UniProtKB/Swiss-Prot
      P12657, Q52KQ0, Q8BJN3
      Related
      ENSMUSP00000042632.4, ENSMUST00000035444.10
      Conserved Domains (1) summary
      cd17790
      Location:26429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8641369..8660970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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