Cntnap5a contactin associated protein-like 5A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cntnap5aprovided by MGI
Official Full Name: contactin associated protein-like 5Aprovided by MGI
Primary source: MGI:MGI:3643623
See related: Ensembl:ENSMUSG00000070695 AllianceGenome:MGI:3643623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Caspr5-1; EG636808
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell adhesion and proteolysis. Predicted to be located in membrane and neuron projection. Is expressed in central nervous system. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 2.7), cortex adult (RPKM 2.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 51.59 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (115612467..116515053)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (115684737..116587323)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the three Caspr5 genes are located on chromosomes 1 & 17; all three paralogs are expressed; common expression is found in brain tissue but different expression patterns are seen in other organs during fetal development and & in the adult stage
Title: New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit188 (e-PCR), detects polymorphism
- UniSTS:128527

M-08387 (e-PCR)
- UniSTS:186240

ha2564 (e-PCR)
- UniSTS:515562

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: contactin-associated protein like 5-1

Names: cell recognition molecule Caspr5-1; cell recognition molecule Caspr5a; contactin-associated protein-like 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077425.2 → NP_001070893.1 contactin-associated protein like 5-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001070893.1

Status: VALIDATED

Source sequence(s)

AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403

Consensus CDS

CCDS35689.1

UniProtKB/Swiss-Prot

Q0V8T9

Related

ENSMUSP00000035732.9, ENSMUST00000043725.9

Conserved Domains (6) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00054
Location:960 → 994

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:56 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:792 → 936

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:550 → 581

EGF; EGF-like domain

pfam02210
Location:395 → 518

Laminin_G_2; Laminin G domain
NM_001371013.1 → NP_001357942.1 contactin-associated protein like 5-1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403

Conserved Domains (6) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00054
Location:961 → 995

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:56 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:793 → 937

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

115612467..116515053

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529774.4 → XP_006529837.1 contactin-associated protein like 5-1 isoform X1

Conserved Domains (6) summary

smart00282
Location:144 → 277

LamG; Laminin G domain

cd00054
Location:900 → 934

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:2 → 112

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:732 → 876

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:490 → 521

EGF; EGF-like domain

pfam02210
Location:335 → 458

Laminin_G_2; Laminin G domain