Cdc42 cell division cycle 42 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc42provided by MGI
Official Full Name: cell division cycle 42provided by MGI
Primary source: MGI:MGI:106211
See related: Ensembl:ENSMUSG00000006699 AllianceGenome:MGI:106211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTP-dependent protein binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including dendritic spine morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including cellular response to type II interferon; filopodium assembly; and positive regulation of intracellular signal transduction. Located in several cellular components, including leading edge membrane; phagocytic vesicle; and storage vacuole. Is active in cell leading edge; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Used to study cleft palate and microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 107.5), placenta adult (RPKM 89.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 69.83 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (137047011..137085007, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (137319696..137357759, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Linear podosomes display low Cdc42 activity for proplatelet elongation by megakaryocytes.
Title: Linear podosomes display low Cdc42 activity for proplatelet elongation by megakaryocytes.
NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
Title: NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
Increased activity of epithelial Cdc42 Rho GTPase and tight junction permeability in the Cftr knockout intestine.
Title: Increased activity of epithelial Cdc42 Rho GTPase and tight junction permeability in the Cftr knockout intestine.
CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.
Title: CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.
Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice.
Title: Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice.
Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion-A Potential Model of Exocrine Gland Senescence.
Title: Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion-A Potential Model of Exocrine Gland Senescence.
ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Title: ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Title: Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs beta-cell insulin secretion.
Title: Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
Cdc42 promotes thyroid cancer cell proliferation and migration and tumor-associated macrophage polarization through the PTEN/AKT pathway.
Title: Cdc42 promotes thyroid cancer cell proliferation and migration and tumor-associated macrophage polarization through the PTEN/AKT pathway.

Submit: New GeneRIF Correction See all GeneRIFs (247)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136515 (e-PCR)
- UniSTS:210497

BB377396 (e-PCR)
- UniSTS:207697

AI747189 (e-PCR)
- UniSTS:179094

Cdc42 (e-PCR), detects polymorphism
- UniSTS:256421

RH126279 (e-PCR)
- UniSTS:162987

UniSTS:224478 (e-PCR)
- UniSTS:224478

Cdc42 (e-PCR), detects polymorphism
- UniSTS:141301

Cdc42 (e-PCR), detects polymorphism
- UniSTS:141302

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GBD domain binding	IEA Inferred from Electronic Annotation more info
enables GBD domain binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables GTP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables apolipoprotein A-I receptor binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	IEA Inferred from Electronic Annotation more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament branching	IEA Inferred from Electronic Annotation more info
involved_in actin filament branching	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac conduction system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dendritic cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	TAS Traceable Author Statement more info	PubMed
involved_in endothelin receptor signaling pathway involved in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of Golgi localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in modification of synaptic structure	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropilin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleus localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle transport along microtubule	IEA Inferred from Electronic Annotation more info
involved_in organelle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pseudopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse structural plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse structural plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of modification of postsynaptic structure	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in submandibular salivary gland formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of Golgi transport complex	IEA Inferred from Electronic Annotation more info
part_of Golgi transport complex	ISO Inferred from Sequence Orthology more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in leading edge membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	HDA more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
located_in storage vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cell division control protein 42 homolog

Names: G25K GTP-binding protein; cell division cycle 42 homolog

NP_001230698.1

EC 3.6.5.2

NP_001407058.1

EC 3.6.5.2

NP_001407059.1

EC 3.6.5.2

NP_001407060.1

EC 3.6.5.2

NP_001407061.1

EC 3.6.5.2

NP_001407062.1

EC 3.6.5.2

NP_001407063.1

EC 3.6.5.2

NP_001407064.1

EC 3.6.5.2

NP_001407065.1

EC 3.6.5.2

NP_033991.1

EC 3.6.5.2

XP_030108999.1

EC 3.6.5.2

XP_030109001.1

EC 3.6.5.2

XP_036019511.1

EC 3.6.5.2

XP_036019512.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243769.2 → NP_001230698.1 cell division control protein 42 homolog isoform 2

See identical proteins and their annotated locations for NP_001230698.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes isoform 2. Variants 2, 8, 9, and 10 encode isoform 2. Isoform 2 is the same length but has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL645468

Consensus CDS

CCDS57305.1

UniProtKB/Swiss-Prot

P60766

Related

ENSMUSP00000030417.10, ENSMUST00000030417.10

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
NM_001420129.1 → NP_001407058.1 cell division control protein 42 homolog isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes isoform 3 which is the same length but has a distinct C-terminus, compared to isoform 4.

Source sequence(s)

AL645468
NM_001420130.1 → NP_001407059.1 cell division control protein 42 homolog isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes isoform 4 which is the same length but has a distinct C-terminus, compared to isoform 3.

Source sequence(s)

AL645468
NM_001420131.1 → NP_001407060.1 cell division control protein 42 homolog isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) encodes isoform 1. Variants 1, 5, 6, and 7 encode isoform 1. Isoform 1 is the same length but has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AL645468

UniProtKB/Swiss-Prot

A2A9U6, P60766, Q3THZ7, Q3TJK6, Q545V0, Q6P201, Q8BQ51
NM_001420132.1 → NP_001407061.1 cell division control protein 42 homolog isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (6) encodes isoform 1. Variants 1, 5, 6, and 7 encode isoform 1. Isoform 1 is the same length but has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AL645468

UniProtKB/Swiss-Prot

A2A9U6, P60766, Q3THZ7, Q3TJK6, Q545V0, Q6P201, Q8BQ51
NM_001420133.1 → NP_001407062.1 cell division control protein 42 homolog isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (7) encodes isoform 1. Variants 1, 5, 6, and 7 encode isoform 1. Isoform 1 is the same length but has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AL645468

UniProtKB/Swiss-Prot

A2A9U6, P60766, Q3THZ7, Q3TJK6, Q545V0, Q6P201, Q8BQ51
NM_001420134.1 → NP_001407063.1 cell division control protein 42 homolog isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (8) encodes isoform 2. Variants 2, 8, 9, and 10 encode isoform 2. Isoform 2 is the same length but has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL645468
NM_001420135.1 → NP_001407064.1 cell division control protein 42 homolog isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (9) encodes isoform 2. Variants 2, 8, 9, and 10 encode isoform 2. Isoform 2 is the same length but has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL645468
NM_001420136.1 → NP_001407065.1 cell division control protein 42 homolog isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (10) encodes isoform 2. Variants 2, 8, 9, and 10 encode isoform 2. Isoform 2 is the same length but has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL645468
NM_009861.4 → NP_033991.1 cell division control protein 42 homolog isoform 1

See identical proteins and their annotated locations for NP_033991.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 5, 6, and 7 encode isoform 1. Isoform 1 is the same length but has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AL645468

Consensus CDS

CCDS18816.1

UniProtKB/Swiss-Prot

A2A9U6, P60766, Q3THZ7, Q3TJK6, Q545V0, Q6P201, Q8BQ51

Related

ENSMUSP00000054634.7, ENSMUST00000051477.13

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RNA

NR_185136.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL645468
NR_185137.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL645468
NR_185138.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL645468
NR_185139.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL645468
NR_185140.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL645468
NR_185141.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL645468

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

137047011..137085007 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253139.2 → XP_030108999.1 cell division control protein 42 homolog isoform X1

UniProtKB/Swiss-Prot

A2A9U6, P60766, Q3THZ7, Q3TJK6, Q545V0, Q6P201, Q8BQ51

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_030253141.2 → XP_030109001.1 cell division control protein 42 homolog isoform X2

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_036163618.1 → XP_036019511.1 cell division control protein 42 homolog isoform X1

UniProtKB/Swiss-Prot

A2A9U6, P60766, Q3THZ7, Q3TJK6, Q545V0, Q6P201, Q8BQ51

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_036163619.1 → XP_036019512.1 cell division control protein 42 homolog isoform X2

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family