Slc9c1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc9c1provided by MGI
Official Full Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1provided by MGI
Primary source: MGI:MGI:2685456
See related: Ensembl:ENSMUSG00000033210 AllianceGenome:MGI:2685456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sNHE; Gm610; NHE-10; Slc9a10; spermNHE
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Acts upstream of or within flagellated sperm motility. Located in motile cilium. Orthologous to human SLC9C1 (solute carrier family 9 member C1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 10.4) See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 29.53 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (45355629..45427364)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (45535266..45607001)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sperm-specific Na+/H+ exchanger is required for the expression of full-length soluble adenylyl cyclase
Title: A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary membrane	TAS Traceable Author Statement more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 9 member C1; sodium/hydrogen exchanger 10

Names: Na(+)/H(+) exchanger 10; solute carrier family 10 member 10; solute carrier family 9, member 10; sperm-specific Na(+)/H(+) exchanger; sperm-specific sodium proton exchanger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198106.4 → NP_932774.3 solute carrier family 9 member C1

See identical proteins and their annotated locations for NP_932774.3

Status: VALIDATED

Source sequence(s)

AC124636

Consensus CDS

CCDS28198.2

UniProtKB/Swiss-Prot

E0CX34, Q6UJY2, Q7M6Y7

Related

ENSMUSP00000124969.2, ENSMUST00000159945.8

Conserved Domains (3) summary

COG0664
Location:885 → 1035

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:895 → 1019

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cl01133
Location:40 → 459

Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

45355629..45427364

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316906.2 → XP_017172395.1 sodium/hydrogen exchanger 10 isoform X3

Conserved Domains (2) summary

cd00038
Location:847 → 971

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cl01133
Location:41 → 309

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_017316905.2 → XP_017172394.1 sodium/hydrogen exchanger 10 isoform X2

Conserved Domains (2) summary

cd00038
Location:853 → 977

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cl01133
Location:40 → 417

Na_H_Exchanger; Sodium/hydrogen exchanger family
XM_017316904.2 → XP_017172393.1 sodium/hydrogen exchanger 10 isoform X1

Conserved Domains (2) summary

cd00038
Location:874 → 998

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cl01133
Location:40 → 438

Na_H_Exchanger; Sodium/hydrogen exchanger family