Zkscan2 zinc finger with KRAB and SCAN domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zkscan2provided by MGI
Official Full Name: zinc finger with KRAB and SCAN domains 2provided by MGI
Primary source: MGI:MGI:2444060
See related: Ensembl:ENSMUSG00000030757 AllianceGenome:MGI:2444060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp694; 9430065N20Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZKSCAN2 (zinc finger with KRAB and SCAN domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 4.7), whole brain E14.5 (RPKM 4.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 67.42 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (123074607..123105685, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (123475384..123505077, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein with KRAB and SCAN domains 2

Names: zinc finger protein 694

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081329.3 → NP_001074798.1 zinc finger protein with KRAB and SCAN domains 2

See identical proteins and their annotated locations for NP_001074798.1

Status: VALIDATED

Source sequence(s)

AC117184

Consensus CDS

CCDS40119.1

UniProtKB/TrEMBL

G3X952

Related

ENSMUSP00000041821.8, ENSMUST00000042470.14

Conserved Domains (9) summary

smart00431
Location:42 → 148

SCAN; leucine rich region

smart00349
Location:241 → 282

KRAB; krueppel associated box

COG5048
Location:766 → 915

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:798 → 818

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:768 → 790

zf-C2H2; Zinc finger, C2H2 type

pfam02023
Location:42 → 129

SCAN; SCAN domain

pfam13465
Location:782 → 806

zf-H2C2_2; Zinc-finger double domain

pfam13837
Location:334 → 415

Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

pfam14510
Location:466 → 505

ABC_trans_N; ABC-transporter extracellular N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

123074607..123105685 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507551.4 → XP_006507614.1 zinc finger protein with KRAB and SCAN domains 2 isoform X2

Conserved Domains (3) summary

COG5048
Location:313 → 462

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:345 → 365

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13837
Location:37 → 122

Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
XM_036152868.1 → XP_036008761.1 zinc finger protein with KRAB and SCAN domains 2 isoform X1

Conserved Domains (3) summary

pfam13837
Location:490 → 571

Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

cl02581
Location:241 → 282

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

cl02605
Location:42 → 148

SCAN; SCAN oligomerization domain

RNA

XR_378227.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175435.2: Suppressed sequence

Description

NM_175435.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.