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    Tagap1 T cell activation GTPase activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 380608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tagap1provided by MGI
    Official Full Name
    T cell activation GTPase activating protein 1provided by MGI
    Primary source
    MGI:MGI:1919786
    See related
    Ensembl:ENSMUSG00000052031 AllianceGenome:MGI:1919786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FKSG15; 2610315E15Rik
    Summary
    Predicted to enable GTPase activator activity. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.9), thymus adult (RPKM 22.7) and 28 other tissues See more
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    Genomic context

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    See Tagap1 in Genome Data Viewer
    Location:
    17 A1; 17 4.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7222364..7246122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6954965..6961565, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122H20 gene Neighboring gene radial spoke 3B homolog (Chlamydomonas) Neighboring gene STARR-positive B cell enhancer mm9_chr17:7165470-7165771 Neighboring gene STARR-positive B cell enhancer ABC_E2470 Neighboring gene STARR-seq mESC enhancer starr_41744 Neighboring gene ribonuclease T2B Neighboring gene predicted gene 1604b Neighboring gene predicted gene, 25119

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel group of multi-GAP-domain proteins. Ruan Y, et al. Mol Reprod Dev, 2008 Oct. PMID 18363199, Free PMC Article
    2. The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Bauer H, et al. Nat Genet, 2005 Sep. PMID 16116428
    3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    T-cell activation GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147155.2 → NP_671511.2  T-cell activation GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_671511.2

      Status: VALIDATED

      Source sequence(s)
      AC122413, AV444953, BQ555561
      Consensus CDS
      CCDS49940.1
      UniProtKB/Swiss-Prot
      P0CAX8
      Related
      ENSMUSP00000070466.7, ENSMUST00000063683.8
      Conserved Domains (1) summary
      cl02570
      Location:52 → 72
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      7222364..7246122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160658.1 → XP_036016551.1  T-cell activation GTPase-activating protein 1 isoform X1

    2. XM_011246178.4 → XP_011244480.1  T-cell activation GTPase-activating protein 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001393.1: Suppressed sequence

      Description
      NM_001001393.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CAX8.1 GenPept UniProtKB/Swiss-Prot:P0CAX8

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