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    Dop1b DOP1 leucine zipper like protein B [ Mus musculus (house mouse) ]

    Gene ID: 70028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dop1bprovided by MGI
    Official Full Name
    DOP1 leucine zipper like protein Bprovided by MGI
    Primary source
    MGI:MGI:1917278
    See related
    Ensembl:ENSMUSG00000022946 AllianceGenome:MGI:1917278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dopey2; C21orf5; mKIAA0933; 0610038M01Rik; 2610510B01Rik
    Summary
    Predicted to be involved in cognition and embryonic pattern specification. Predicted to be located in early endosome membrane. Predicted to be active in endosome and trans-Golgi network. Is expressed in several structures, including early conceptus; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 11.3), lung adult (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dop1b in Genome Data Viewer
    Location:
    16 C4; 16 54.63 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93508795..93607476)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93711907..93810588)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 3 Neighboring gene STARR-positive B cell enhancer ABC_E5562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93711280-93711389 Neighboring gene STARR-positive B cell enhancer ABC_E1497 Neighboring gene STARR-seq mESC enhancer starr_41539 Neighboring gene predicted gene, 41501 Neighboring gene RIKEN cDNA 2310043M15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:93798797-93799098 Neighboring gene STARR-positive B cell enhancer ABC_E7479 Neighboring gene predicted gene, 30881 Neighboring gene STARR-seq mESC enhancer starr_41543 Neighboring gene STARR-positive B cell enhancer ABC_E7480 Neighboring gene STARR-positive B cell enhancer ABC_E3176 Neighboring gene STARR-seq mESC enhancer starr_41545 Neighboring gene microrchidia 3 Neighboring gene STARR-positive B cell enhancer ABC_E3177 Neighboring gene chromatin assembly factor 1, subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New cerebellar phenotypes in YAC transgenic mouse in vivo library of human Down syndrome critical region-1. Rachidi M, et al. Biochem Biophys Res Commun, 2007 Dec 21. PMID 17963726
    2. The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. Lopes C, et al. Biochem Biophys Res Commun, 2003 Jun 13. PMID 12767918
    3. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
    4. Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21. Pletcher MT, et al. Genomics, 2001 May 15. PMID 11374901
    5. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We proposed DOPEY2 as potential candidate gene for these cerebellar alterations considering its high expression in the brain.
      Title: New cerebellar phenotypes in YAC transgenic mouse in vivo library of human Down syndrome critical region-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein DOP1B; protein dopey-2
    Names
    dopey family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357118.1 → NP_001344047.1  protein DOP1B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154449, AC168220
      Consensus CDS
      CCDS88972.1
      UniProtKB/TrEMBL
      A0A2I3BRZ2
      Related
      ENSMUSP00000154771.2, ENSMUST00000227156.2
      Conserved Domains (2) summary
      pfam04118
      Location:1 → 186
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1832 → 1980
      Dopey_N; Dopey, N-terminal

    2. NM_026700.2 → NP_080976.1  protein DOP1B isoform 2

      See identical proteins and their annotated locations for NP_080976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. The encoded isoform 2 has a much shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK002808, AK147255, BY195296
      UniProtKB/TrEMBL
      Q9DCG4
      Conserved Domains (1) summary
      pfam04118
      Location:13 → 176
      Dopey_N; Dopey, N-terminal

    3. NM_027293.1 → NP_081569.1  protein DOP1B isoform 1

      See identical proteins and their annotated locations for NP_081569.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK147255, BC057081, BC075639, BE945779, BY195296
      Consensus CDS
      CCDS28343.1
      UniProtKB/Swiss-Prot
      E9QLV2, Q3UH78, Q3UHQ6, Q80TN8
      Related
      ENSMUSP00000044437.10, ENSMUST00000045004.11
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 308
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1949 → 2097
      Dopey_N; Dopey, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      93508795..93607476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246143.1 → XP_011244445.1  protein dopey-2 isoform X1

      See identical proteins and their annotated locations for XP_011244445.1

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1987 → 2135
      Dopey_N; Dopey, N-terminal

    2. XM_006523080.2 → XP_006523143.1  protein dopey-2 isoform X7

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1950 → 2098
      Dopey_N; Dopey, N-terminal

    3. XM_011246145.2 → XP_011244447.1  protein dopey-2 isoform X2

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1986 → 2134
      Dopey_N; Dopey, N-terminal

    4. XM_011246146.2 → XP_011244448.1  protein dopey-2 isoform X3

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1975 → 2123
      Dopey_N; Dopey, N-terminal

    5. XM_017317127.2 → XP_017172616.1  protein dopey-2 isoform X4

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1974 → 2122
      Dopey_N; Dopey, N-terminal

    6. XM_006523077.2 → XP_006523140.1  protein dopey-2 isoform X5

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1962 → 2110
      Dopey_N; Dopey, N-terminal

    7. XM_017317128.2 → XP_017172617.1  protein dopey-2 isoform X6

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1961 → 2109
      Dopey_N; Dopey, N-terminal

    8. XM_011246150.2 → XP_011244452.1  protein dopey-2 isoform X11

      Conserved Domains (1) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal

    9. XM_036160109.1 → XP_036016002.1  protein dopey-2 isoform X8

      Conserved Domains (2) summary
      pfam04118
      Location:1 → 186
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1869 → 2095
      Dopey_N; Dopey, N-terminal

    10. XM_030249264.2 → XP_030105124.1  protein dopey-2 isoform X9

      Conserved Domains (1) summary
      cl04407
      Location:1 → 86
      Dopey_N; Dopey, N-terminal

    11. XM_030249265.2 → XP_030105125.1  protein dopey-2 isoform X10

      Conserved Domains (1) summary
      cl04407
      Location:1698 → 1924
      Dopey_N; Dopey, N-terminal

    12. XM_011246144.2 → XP_011244446.1  protein dopey-2 isoform X1

      See identical proteins and their annotated locations for XP_011244446.1

      Conserved Domains (2) summary
      pfam04118
      Location:13 → 304
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1987 → 2135
      Dopey_N; Dopey, N-terminal

    13. XM_036160110.1 → XP_036016003.1  protein dopey-2 isoform X8

      Conserved Domains (2) summary
      pfam04118
      Location:1 → 186
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1869 → 2095
      Dopey_N; Dopey, N-terminal

    14. XM_030249266.2 → XP_030105126.1  protein dopey-2 isoform X10

      Conserved Domains (1) summary
      cl04407
      Location:1698 → 1924
      Dopey_N; Dopey, N-terminal

    15. XM_011246147.4 → XP_011244449.1  protein dopey-2 isoform X8

      Conserved Domains (2) summary
      pfam04118
      Location:1 → 186
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:1869 → 2095
      Dopey_N; Dopey, N-terminal

    RNA

    1. XR_876136.1 RNA Sequence

    2. XR_004939217.1 RNA Sequence

    3. XR_001781857.1 RNA Sequence

    4. XR_001781858.1 RNA Sequence

    5. XR_004939218.1 RNA Sequence

    6. XR_001781860.1 RNA Sequence

    7. XR_004939219.1 RNA Sequence

    8. XR_003951828.1 RNA Sequence

    9. XR_004939220.1 RNA Sequence

    10. XR_876139.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHQ6.3 GenPept UniProtKB/Swiss-Prot:Q3UHQ6

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