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    Arhgap45 Rho GTPase activating protein 45 [ Mus musculus (house mouse) ]

    Gene ID: 70719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap45provided by MGI
    Official Full Name
    Rho GTPase activating protein 45provided by MGI
    Primary source
    MGI:MGI:1917969
    See related
    Ensembl:ENSMUSG00000035697 AllianceGenome:MGI:1917969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ha-1; Hmha1; 6330406L22Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 412.6), spleen adult (RPKM 216.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap45 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79852505..79867305)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80016672..80031471)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1805 Neighboring gene ATP-binding cassette, sub-family A member 7 Neighboring gene STARR-positive B cell enhancer ABC_E2948 Neighboring gene STARR-positive B cell enhancer ABC_E6880 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide E Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding. He L, et al. EMBO Rep, 2021 Apr 7. PMID 33719206, Free PMC Article
    2. Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics. Voisinne G, et al. Nat Immunol, 2019 Nov. PMID 31591574, Free PMC Article
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0223

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 45
    Names
    histocompatibility (minor) HA-1
    minor histocompatibility protein HA-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142701.1 → NP_001136173.1  rho GTPase-activating protein 45 isoform 1

      See identical proteins and their annotated locations for NP_001136173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK159194, AK159474, BB733889
      Consensus CDS
      CCDS48624.1
      UniProtKB/Swiss-Prot
      Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
      UniProtKB/TrEMBL
      G3X9Q3
      Related
      ENSMUSP00000097100.4, ENSMUST00000099501.10
      Conserved Domains (3) summary
      smart00109
      Location:699 → 744
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:756 → 966
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:278 → 529
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001347074.1 → NP_001334003.1  rho GTPase-activating protein 45 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AI430932, AK151423, AK159194, AK159474, BY168122
      Consensus CDS
      CCDS83725.1
      UniProtKB/Swiss-Prot
      Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
      UniProtKB/TrEMBL
      D3Z7R7
      Related
      ENSMUSP00000101012.2, ENSMUST00000105373.8

    3. NM_027521.3 → NP_081797.1  rho GTPase-activating protein 45 isoform 2

      See identical proteins and their annotated locations for NP_081797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, as compared to isoform 1.
      Source sequence(s)
      BB733889, BC053750
      Consensus CDS
      CCDS24005.1
      UniProtKB/Swiss-Prot
      Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
      Related
      ENSMUSP00000041019.7, ENSMUST00000043311.7
      Conserved Domains (3) summary
      smart00109
      Location:583 → 628
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:640 → 850
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:162 → 413
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79852505..79867305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245276.2 → XP_030101136.1  rho GTPase-activating protein 45 isoform X3

      Related
      ENSMUST00000140974.8
      Conserved Domains (2) summary
      smart00109
      Location:172 → 217
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:229 → 439
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    2. XM_006514109.2 → XP_006514172.1  rho GTPase-activating protein 45 isoform X1

      UniProtKB/Swiss-Prot
      Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
      Conserved Domains (3) summary
      smart00109
      Location:540 → 585
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:597 → 807
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:119 → 370
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_006514110.1 → XP_006514173.1  rho GTPase-activating protein 45 isoform X2

      Related
      ENSMUST00000150022.2
      Conserved Domains (3) summary
      smart00109
      Location:458 → 503
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:515 → 725
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:37 → 288
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001779599.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TBD2.2 GenPept UniProtKB/Swiss-Prot:Q3TBD2

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