Impa2 inositol monophosphatase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Impa2provided by MGI
Official Full Name: inositol monophosphatase 2provided by MGI
Primary source: MGI:MGI:2149728
See related: Ensembl:ENSMUSG00000024525 AllianceGenome:MGI:2149728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMP 2; IMPase 2; 2210415D20Rik
Summary: Predicted to enable inositol monophosphate 1-phosphatase activity and protein homodimerization activity. Predicted to be involved in inositol metabolic process; response to lithium ion; and signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 11.6), limb E14.5 (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 39.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (67422246..67454375)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (67289247..67319216)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IMPA2 has a separate function in vivo from that of IMPA1
Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237832

AW259601 (e-PCR)
- UniSTS:181140

AI326924 (e-PCR)
- UniSTS:160756

Impa2 (e-PCR), detects polymorphism
- UniSTS:528630

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inositol metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to lithium ion	IEA Inferred from Electronic Annotation more info
involved_in response to lithium ion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: inositol monophosphatase 2

Names: inositol (myo)-1(or 4)-monophosphatase 2; myo-inositol monophosphatase A2

NP_444491.1

EC 3.1.3.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053261.3 → NP_444491.1 inositol monophosphatase 2

See identical proteins and their annotated locations for NP_444491.1

Status: VALIDATED

Source sequence(s)

AC154125

Consensus CDS

CCDS29320.1

UniProtKB/Swiss-Prot

Q91UZ5

UniProtKB/TrEMBL

Q3TAU6, Q3U3B7

Related

ENSMUSP00000025403.7, ENSMUST00000025403.8

Conserved Domains (1) summary

cd01639
Location:21 → 266

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...