Clec12b C-type lectin domain family 12, member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec12bprovided by MGI
Official Full Name: C-type lectin domain family 12, member Bprovided by MGI
Primary source: MGI:MGI:1918433
See related: Ensembl:ENSMUSG00000030158 AllianceGenome:MGI:1918433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933425B16Rik
Summary: Predicted to enable protein phosphatase binding activity and signaling receptor inhibitor activity. Predicted to be involved in several processes, including melanocyte proliferation; natural killer cell inhibitory signaling pathway; and regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC12B (C-type lectin domain family 12 member B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 1.4), lung adult (RPKM 1.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.28 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129352476..129404597, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129375513..129427634, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components.
Title: CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components.
Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
Title: Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in melanocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell inhibitory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell inhibitory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 12 member B

Names: macrophage antigen h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204223.1 → NP_001191152.1 C-type lectin domain family 12 member B

See identical proteins and their annotated locations for NP_001191152.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC138620

Consensus CDS

CCDS51922.1

UniProtKB/Swiss-Prot

Q149M0, Q9D403

UniProtKB/TrEMBL

A0A0R4J0A7

Related

ENSMUSP00000107713.4, ENSMUST00000112082.9

Conserved Domains (1) summary

cd03593
Location:142 → 264

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_027709.2 → NP_081985.1 C-type lectin domain family 12 member B

See identical proteins and their annotated locations for NP_081985.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK016908, AV319772

Consensus CDS

CCDS51922.1

UniProtKB/Swiss-Prot

Q149M0, Q9D403

UniProtKB/TrEMBL

A0A0R4J0A7

Related

ENSMUSP00000032261.7, ENSMUST00000032261.9

Conserved Domains (1) summary

cd03593
Location:142 → 264

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129352476..129404597 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241466.1 → XP_011239768.1 C-type lectin domain family 12 member B isoform X1

See identical proteins and their annotated locations for XP_011239768.1

UniProtKB/Swiss-Prot

Q149M0, Q9D403

Conserved Domains (1) summary

cd03593
Location:145 → 267

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_006506612.2 → XP_006506675.1 C-type lectin domain family 12 member B isoform X2

See identical proteins and their annotated locations for XP_006506675.1

UniProtKB/Swiss-Prot

Q149M0, Q9D403

UniProtKB/TrEMBL

A0A0R4J0A7

Conserved Domains (1) summary

cd03593
Location:142 → 264

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)