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    Kif20a kinesin family member 20A [ Mus musculus (house mouse) ]

    Gene ID: 19348, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kif20aprovided by MGI
    Official Full Name
    kinesin family member 20Aprovided by MGI
    Primary source
    MGI:MGI:1201682
    See related
    Ensembl:ENSMUSG00000003779 AllianceGenome:MGI:1201682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab6kifl
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Predicted to be located in several cellular components, including intercellular bridge; midbody; and spindle. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Is expressed in 4-cell stage embryo; brain; genitourinary system; and stomach. Human ortholog(s) of this gene implicated in restrictive cardiomyopathy. Orthologous to human KIF20A (kinesin family member 20A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 32.7), liver E14 (RPKM 27.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif20a in Genome Data Viewer
    Location:
    18 B1; 18 18.69 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34757677..34766330)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34624624..34633277)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene BRD8 domain containing Neighboring gene bromodomain containing 8 Neighboring gene predicted gene, 41688 Neighboring gene STARR-positive B cell enhancer ABC_E4242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34784160-34784348 Neighboring gene STARR-positive B cell enhancer ABC_E963 Neighboring gene STARR-seq mESC enhancer starr_44210 Neighboring gene CDC23 cell division cycle 23 Neighboring gene STARR-seq mESC enhancer starr_44211 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kinesin-6 family motor KIF20A regulates central spindle assembly and acrosome biogenesis in mouse spermatogenesis. She ZY, et al. Biochim Biophys Acta Mol Cell Res, 2020 Apr. PMID 31884069
    2. A kinesin is present at unique sertoli/spermatid adherens junctions in rat and mouse testes. Vaid KS, et al. Biol Reprod, 2007 Dec. PMID 17855729
    3. KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis. Gasnereau I, et al. Am J Pathol, 2012 Jan. PMID 22056911
    4. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Qiu R, et al. Commun Biol, 2021 May 11. PMID 33976373, Free PMC Article
    5. SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development. Qiu R, et al. Cereb Cortex, 2020 May 14. PMID 31813992, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.
      Title: SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.
    2. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
      Title: Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
    3. KIF20A binds the microtubules to organize the central spindle assembly during spermatogenesis.
      Title: Kinesin-6 family motor KIF20A regulates central spindle assembly and acrosome biogenesis in mouse spermatogenesis.
    4. It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis.
      Title: KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbody abscission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF20A
    Names
    Rabkinesin-6
    kinesin-like protein 174
    rab6-interacting kinesin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166406.1 → NP_001159878.1  kinesin-like protein KIF20A

      See identical proteins and their annotated locations for NP_001159878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK084732, BC060608
      Consensus CDS
      CCDS29131.1
      UniProtKB/Swiss-Prot
      P97329, Q542M4
      Related
      ENSMUSP00000132659.2, ENSMUST00000166044.3
      Conserved Domains (4) summary
      cd01368
      Location:62 → 504
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:69 → 505
      Kinesin; Kinesin motor domain
      cd16269
      Location:620 → 631
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:536 → 651
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001166407.1 → NP_001159879.1  kinesin-like protein KIF20A

      See identical proteins and their annotated locations for NP_001159879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC074335, AK084732, AK144844
      Consensus CDS
      CCDS29131.1
      UniProtKB/Swiss-Prot
      P97329, Q542M4
      Related
      ENSMUSP00000130045.2, ENSMUST00000167161.9
      Conserved Domains (4) summary
      cd01368
      Location:62 → 504
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:69 → 505
      Kinesin; Kinesin motor domain
      cd16269
      Location:620 → 631
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:536 → 651
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_009004.4 → NP_033030.1  kinesin-like protein KIF20A

      See identical proteins and their annotated locations for NP_033030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK084732, AK144844, BY012551
      Consensus CDS
      CCDS29131.1
      UniProtKB/Swiss-Prot
      P97329, Q542M4
      Related
      ENSMUSP00000157839.2, ENSMUST00000237407.2
      Conserved Domains (4) summary
      cd01368
      Location:62 → 504
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:69 → 505
      Kinesin; Kinesin motor domain
      cd16269
      Location:620 → 631
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:536 → 651
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34757677..34766330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97329.1 GenPept UniProtKB/Swiss-Prot:P97329

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