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    CCNE2 cyclin E2 [ Homo sapiens (human) ]

    Gene ID: 9134, updated on 10-Dec-2024

    Summary

    Official Symbol
    CCNE2provided by HGNC
    Official Full Name
    cyclin E2provided by HGNC
    Primary source
    HGNC:HGNC:1590
    See related
    Ensembl:ENSG00000175305 MIM:603775; AllianceGenome:HGNC:1590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYCE2
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See CCNE2 in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94880224..94896693, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (96005210..96021694, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95892452..95907429, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ribosomal protein S15a pseudogene 26 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:95731221-95732175 Neighboring gene dpy-19 like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27635 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95906241-95906802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27636 Neighboring gene small nucleolar RNA U13 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:95960947-95961575 and GRCh37_chr8:95961576-95962205 Neighboring gene tumor protein p53 inducible nuclear protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of cyclin E1-CDK2 complex  
    part_of cyclin E2-CDK2 complex  
    part_of cyclin E2-CDK2 complex PubMed 
    is_active_in cytoplasm  
    located_in cytosol  
    is_active_in microtubule organizing center  
    located_in nucleoplasm  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029611.1 RefSeqGene

      Range
      5054..20031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057749.3 → NP_477097.1  G1/S-specific cyclin-E2

      See identical proteins and their annotated locations for NP_477097.1

      Status: REVIEWED

      Source sequence(s)
      AF091433, BJ990268, DB547256
      Consensus CDS
      CCDS6264.1
      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
      Related
      ENSP00000309181.4, ENST00000308108.9
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      94880224..94896693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013958.2 → XP_016869447.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
      Related
      ENSP00000429089.1, ENST00000520509.5
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain
    2. XM_047422411.1 → XP_047278367.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
    3. XM_017013959.2 → XP_016869448.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain
    4. XM_011517366.3 → XP_011515668.1  G1/S-specific cyclin-E2 isoform X2

      Conserved Domains (1) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      96005210..96021694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361489.1 → XP_054217464.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
    2. XM_054361491.1 → XP_054217466.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
    3. XM_054361490.1 → XP_054217465.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
    4. XM_054361492.1 → XP_054217467.1  G1/S-specific cyclin-E2 isoform X2

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