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    RHOV ras homolog family member V [ Homo sapiens (human) ]

    Gene ID: 171177, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RHOVprovided by HGNC
    Official Full Name
    ras homolog family member Vprovided by HGNC
    Primary source
    HGNC:HGNC:18313
    See related
    Ensembl:ENSG00000104140 MIM:620101; AllianceGenome:HGNC:18313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHP; ARHV; WRCH2
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be located in endosome membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in esophagus (RPKM 34.6), skin (RPKM 27.2) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RHOV in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40872214..40874234, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38678234..38680254, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41164412..41166432, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41117412-41117912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41117913-41118413 Neighboring gene Sharpr-MPRA regulatory region 7770 Neighboring gene SPINT1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41135684-41135866 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41135819-41136390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6344 Neighboring gene serine peptidase inhibitor, Kunitz type 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9268 Neighboring gene uncharacterized LOC124903475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9270 Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene Sharpr-MPRA regulatory region 6315 Neighboring gene uncharacterized LOC105370943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9271

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis. Qin Q, et al. FEBS Open Bio, 2023 Nov. PMID 37596964, Free PMC Article
    2. The Rho GTPase family: a Racs to Wrchs story. Wherlock M, et al. J Cell Sci, 2002 Jan 15. PMID 11839775
    3. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. Katoh M. Int J Oncol, 2002 May. PMID 11956592
    4. Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. Chenette EJ, et al. J Biol Chem, 2005 Apr 8. PMID 15664990
    5. The RHOV gene is overexpressed in human non-small cell lung cancer. Shepelev MV, et al. Cancer Genet, 2013 Nov. PMID 24388711

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA.
      Title: Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA.
    2. Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis.
      Title: Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis.
    3. In vivo CRISPR screens identify RhoV as a pro-metastasis factor of triple-negative breast cancer.
      Title: In vivo CRISPR screens identify RhoV as a pro-metastasis factor of triple-negative breast cancer.
    4. RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.
      Title: RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.
    5. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.
      Title: A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.
    6. Our results suggest that the effector domain of RhoV mediates its binding to Pak1, complementing the current view of the molecular basics of RhoV binding to effectors of the Pak family.
      Title: [Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase].
    7. This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch.
      Title: Atypical RhoV and RhoU GTPases control development of the neural crest.
    8. Authors propose that the RHOV gene could be validated as a diagnostic or prognostic marker for NSCLC, and that observed overexpression of RHOV might contribute to tumorigenesis.
      Title: The RHOV gene is overexpressed in human non-small cell lung cancer.
    9. CDC42 homologous protein does not enhance the level of Ser60 phosphorylation in Pak6. (RHO V protein)
      Title: Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV.
    10. Results demonstrate a novel mechanism of signal termination mediated by the Rho-family GTPases Chp and Cdc42, which results in ubiquitin-mediated degradation of one of their direct effectors, Pak1.
      Title: Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoV
    Names
    CDC42-like GTPase 2
    GTP-binding protein-like 2
    Rho GTPase-like protein ARHV
    WRCH-2
    WRCH1-related GTPase
    Wnt-1 regulated Cdc42 homolog 2
    Wnt-1 responsive Cdc42 homolog 2
    ras homolog gene family, member V

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133639.4 → NP_598378.3  rho-related GTP-binding protein RhoV

      See identical proteins and their annotated locations for NP_598378.3

      Status: VALIDATED

      Source sequence(s)
      AC025166, BC112945
      Consensus CDS
      CCDS10068.1
      UniProtKB/Swiss-Prot
      Q2KHQ5, Q8TDW6, Q96L33
      UniProtKB/TrEMBL
      Q05D03
      Related
      ENSP00000220507.4, ENST00000220507.5
      Conserved Domains (1) summary
      cd04130
      Location:32 → 205
      Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      40872214..40874234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      38678234..38680254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96L33.1 GenPept UniProtKB/Swiss-Prot:Q96L33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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