U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    LILRA4 leukocyte immunoglobulin like receptor A4 [ Homo sapiens (human) ]

    Gene ID: 23547, updated on 10-Dec-2024

    Summary

    Official Symbol
    LILRA4provided by HGNC
    Official Full Name
    leukocyte immunoglobulin like receptor A4provided by HGNC
    Primary source
    HGNC:HGNC:15503
    See related
    Ensembl:ENSG00000239961 MIM:607517; AllianceGenome:HGNC:15503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILT7; CD85g
    Summary
    This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]
    Expression
    Biased expression in spleen (RPKM 5.0), lymph node (RPKM 4.4) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LILRA4 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54333185..54339162, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57422956..57428933, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54844456..54850433, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene Sharpr-MPRA regulatory region 7396 Neighboring gene vomeronasal 1 receptor 104 pseudogene Neighboring gene MPRA-validated peak3554 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54868647-54869166 Neighboring gene leukocyte associated immunoglobulin like receptor 1 Neighboring gene NANOG hESC enhancer GRCh37_chr19:54903053-54903600 Neighboring gene LIM domain-containing protein A-like Neighboring gene tweety family member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu Vpu-mediated suppresion of IFN-1 production requires engagement and activation of the LILRA4 (ILT7) plasmacytoid dendritic cell receptor by BST2 PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

    Potential readthrough

    Included gene: LILRA5

    Clone Names

    • MGC129597, MGC129598

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity PubMed 
    enables inhibitory MHC class I receptor activity  
    enables protein binding PubMed 
    enables signaling receptor binding PubMed 
    Component Evidence Code Pubs
    part_of Fc-epsilon receptor I complex PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily A member 4
    Names
    CD85 antigen-like family member G
    immunoglobulin-like transcript 7
    leucocyte Ig-like receptor A4
    leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
    leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012276.5 → NP_036408.4  leukocyte immunoglobulin-like receptor subfamily A member 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC245884, AF283989, BI834628, DA983933
      Consensus CDS
      CCDS12890.1
      UniProtKB/Swiss-Prot
      P59901, Q32MC4
      UniProtKB/TrEMBL
      A0A0G2JNG2
      Related
      ENSP00000291759.4, ENST00000291759.5
      Conserved Domains (2) summary
      smart00410
      Location:233 → 295
      IG_like; Immunoglobulin like
      cl11960
      Location:122 → 217
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54333185..54339162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      314530..320509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      314684..320663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      315570..321547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57422956..57428933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Loading
    External link. Please review our privacy policy.