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    LATS1 large tumor suppressor kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9113, updated on 27-Nov-2024

    Summary

    Official Symbol
    LATS1provided by HGNC
    Official Full Name
    large tumor suppressor kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:6514
    See related
    Ensembl:ENSG00000131023 MIM:603473; AllianceGenome:HGNC:6514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    wts; WARTS
    Summary
    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LATS1 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149658153..149718101, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150857942..150917878, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149979289..150039237, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene katanin catalytic subunit A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17664 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:150022675-150023256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17665 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:150045663-150045865 Neighboring gene uncharacterized LOC645967 Neighboring gene nucleoporin 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:150069877-150070842 Neighboring gene Sharpr-MPRA regulatory region 3985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150071808-150072310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150072311-150072813 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:150106480-150106982 Neighboring gene BTB domain containing 10 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic sequestering of protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hippo signaling TAS
    Traceable Author Statement
    more info
     
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inner cell mass cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner cell mass cellular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase LATS1
    Names
    LATS (large tumor suppressor, Drosophila) homolog 1
    LATS, large tumor suppressor, homolog 1
    WARTS protein kinase
    h-warts
    large tumor suppressor homolog 1
    NP_001257448.1
    NP_001337268.1
    NP_001337269.1
    NP_001337321.1
    NP_004681.1
    XP_006715666.1
    XP_011534554.1
    XP_016866963.1
    XP_016866966.1
    XP_016866968.1
    XP_024302351.1
    XP_047275473.1
    XP_047275474.1
    XP_047275475.1
    XP_047275477.1
    XP_047275478.1
    XP_054212719.1
    XP_054212720.1
    XP_054212721.1
    XP_054212722.1
    XP_054212723.1
    XP_054212724.1
    XP_054212725.1
    XP_054212726.1
    XP_054212727.1
    XP_054212728.1
    XP_054212729.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270519.2NP_001257448.1  serine/threonine-protein kinase LATS1 isoform 2

      See identical proteins and their annotated locations for NP_001257448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF104413, AL358852, AL583963, BC002767
      Consensus CDS
      CCDS59040.1
      UniProtKB/Swiss-Prot
      O95835
      Related
      ENSP00000444678.1, ENST00000392273.7
      Conserved Domains (3) summary
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl26247
      Location:473558
      DNA_pol3_delta2; DNA polymerase III, delta subunit
      cl28087
      Location:467673
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001350339.2NP_001337268.1  serine/threonine-protein kinase LATS1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform 3.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (3) summary
      cl21453
      Location:5981012
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:1138
      UBA_like_SF; UBA domain-like superfamily
      cl28087
      Location:343491
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    3. NM_001350340.2NP_001337269.1  serine/threonine-protein kinase LATS1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform 4.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (3) summary
      cd05625
      Location:598979
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl21463
      Location:1138
      UBA_like_SF; UBA domain-like superfamily
      cl28087
      Location:343491
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    4. NM_001350392.2NP_001337321.1  serine/threonine-protein kinase LATS1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform 5.
      Source sequence(s)
      AL358852, AL583963, BX276089
      UniProtKB/TrEMBL
      Q59FN4
      Conserved Domains (2) summary
      cd05625
      Location:423804
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl26464
      Location:9312
      Atrophin-1; Atrophin-1 family
    5. NM_004690.4NP_004681.1  serine/threonine-protein kinase LATS1 isoform 1

      See identical proteins and their annotated locations for NP_004681.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF104413, AL358852, AW021064, BX276089
      Consensus CDS
      CCDS34551.1
      UniProtKB/Swiss-Prot
      O95835, Q6PKD0
      Related
      ENSP00000437550.1, ENST00000543571.6
      Conserved Domains (3) summary
      smart00220
      Location:7051010
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cd05625
      Location:7031084
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

    RNA

    1. NR_073033.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
      Source sequence(s)
      AK310422, AW021064, BX276089

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149658153..149718101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011474.2XP_016866963.1  serine/threonine-protein kinase LATS1 isoform X1

      Conserved Domains (3) summary
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:7031117
      PKc_like; Protein Kinases, catalytic domain
      cl28087
      Location:448596
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    2. XM_024446583.2XP_024302351.1  serine/threonine-protein kinase LATS1 isoform X1

      Conserved Domains (3) summary
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:7031117
      PKc_like; Protein Kinases, catalytic domain
      cl28087
      Location:448596
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    3. XM_047419518.1XP_047275474.1  serine/threonine-protein kinase LATS1 isoform X2

      UniProtKB/Swiss-Prot
      O95835, Q6PKD0
      Related
      ENSP00000253339.5, ENST00000253339.9
    4. XM_047419517.1XP_047275473.1  serine/threonine-protein kinase LATS1 isoform X1

    5. XM_047419521.1XP_047275477.1  serine/threonine-protein kinase LATS1 isoform X8

    6. XM_017011479.2XP_016866968.1  serine/threonine-protein kinase LATS1 isoform X6

      UniProtKB/TrEMBL
      Q59FN4
    7. XM_011536252.3XP_011534554.1  serine/threonine-protein kinase LATS1 isoform X4

      UniProtKB/TrEMBL
      Q59FN4
      Conserved Domains (3) summary
      smart00220
      Location:705961
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703961
      PKc_like; Protein Kinases, catalytic domain
    8. XM_017011477.2XP_016866966.1  serine/threonine-protein kinase LATS1 isoform X3

    9. XM_047419519.1XP_047275475.1  serine/threonine-protein kinase LATS1 isoform X5

    10. XM_006715603.4XP_006715666.1  serine/threonine-protein kinase LATS1 isoform X7

      UniProtKB/TrEMBL
      Q59FN4
      Conserved Domains (3) summary
      smart00220
      Location:705862
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703863
      PKc_like; Protein Kinases, catalytic domain
    11. XM_047419522.1XP_047275478.1  serine/threonine-protein kinase LATS1 isoform X9

    RNA

    1. XR_007059386.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      150857942..150917878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356744.1XP_054212719.1  serine/threonine-protein kinase LATS1 isoform X1

    2. XM_054356745.1XP_054212720.1  serine/threonine-protein kinase LATS1 isoform X1

    3. XM_054356747.1XP_054212722.1  serine/threonine-protein kinase LATS1 isoform X2

      UniProtKB/Swiss-Prot
      O95835, Q6PKD0
    4. XM_054356746.1XP_054212721.1  serine/threonine-protein kinase LATS1 isoform X1

    5. XM_054356753.1XP_054212728.1  serine/threonine-protein kinase LATS1 isoform X8

    6. XM_054356751.1XP_054212726.1  serine/threonine-protein kinase LATS1 isoform X6

    7. XM_054356749.1XP_054212724.1  serine/threonine-protein kinase LATS1 isoform X4

    8. XM_054356748.1XP_054212723.1  serine/threonine-protein kinase LATS1 isoform X3

    9. XM_054356750.1XP_054212725.1  serine/threonine-protein kinase LATS1 isoform X5

    10. XM_054356752.1XP_054212727.1  serine/threonine-protein kinase LATS1 isoform X7

    11. XM_054356754.1XP_054212729.1  serine/threonine-protein kinase LATS1 isoform X9

    RNA

    1. XR_008487506.1 RNA Sequence