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    FHIP2B FHF complex subunit HOOK interacting protein 2B [ Homo sapiens (human) ]

    Gene ID: 64760, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FHIP2Bprovided by HGNC
    Official Full Name
    FHF complex subunit HOOK interacting protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:16492
    See related
    Ensembl:ENSG00000158863 MIM:620230; AllianceGenome:HGNC:16492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAI16; RAI16; FAM160B2; RAM160B2
    Expression
    Ubiquitous expression in skin (RPKM 11.2), prostate (RPKM 9.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FHIP2B in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22089150..22104911)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22363108..22378867)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21946661..21962422)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903342-21903848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903849-21904354 Neighboring gene fibroblast growth factor 17 Neighboring gene VISTA enhancer hs781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21908959-21909751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21915443-21916404 Neighboring gene dematin actin binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21917368-21918329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21943692-21944301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21951526-21952026 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21961808-21961955 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 8:21964802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21965271-21966044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21969459-21969958 Neighboring gene nudix hydrolase 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21972531-21973193 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21977874-21978076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21978415-21978914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21981891-21982392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21982393-21982892 Neighboring gene HR lysine demethylase and nuclear receptor corepressor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21987125-21987702 Neighboring gene HR upstream open reading frame

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70. Ding CL, et al. Oncotarget, 2015 Jun 20. PMID 25900241, Free PMC Article
    2. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma. Wang W, et al. Carcinogenesis, 2012 Dec. PMID 22971576
    3. Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells. Ding CL, et al. Mol Cell Endocrinol, 2020 Apr 15. PMID 32014455
    4. Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice. Xu YL, et al. Cell Death Dis, 2019 Dec 20. PMID 31862898, Free PMC Article
    5. FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems. Mavioğlu RN, et al. Clin Genet, 2019 Nov. PMID 31353455

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells.
      Title: Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells.
    2. Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.
      Title: Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.
    3. FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems.
      Title: FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems.
    4. RAI16 interacted with the type II regulatory subunit of protein kinase A(PKA-RIIalpha), acting as a novel protein kinase A anchoring protein (AKAP). In addition, RAI16 also interacted with heat shock protein 70 (HSP70) and 14-3-3theta;.
      Title: Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70.
    5. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma.
      Title: Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11125, FLJ21801, MGC138352

    General protein information

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    Preferred Names
    FHF complex subunit HOOK-interacting protein 2B
    Names
    family with sequence similarity 160 member B2
    protein FAM160B2
    retinoic acid induced 16
    retinoic acid-induced protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354250.2 → NP_001341179.1  FHF complex subunit HOOK-interacting protein 2B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC091171
      Conserved Domains (1) summary
      pfam10257
      Location:79 → 475
      RAI16-like; Retinoic acid induced 16-like protein

    2. NM_001354251.2 → NP_001341180.1  FHF complex subunit HOOK-interacting protein 2B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC091171
      Conserved Domains (1) summary
      pfam10257
      Location:21 → 418
      RAI16-like; Retinoic acid induced 16-like protein

    3. NM_022749.7 → NP_073586.5  FHF complex subunit HOOK-interacting protein 2B isoform 1

      See identical proteins and their annotated locations for NP_073586.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC091171
      Consensus CDS
      CCDS6021.2
      UniProtKB/Swiss-Prot
      B2RDQ5, B3KNX1, Q2M211, Q71JB5, Q7L3J6, Q86V87, Q969T0, Q9H6W4
      Related
      ENSP00000289921.6, ENST00000289921.8
      Conserved Domains (1) summary
      pfam10257
      Location:79 → 476
      RAI16-like; Retinoic acid induced 16-like protein

    RNA

    1. NR_148727.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171, BC052237, HY033313

    2. NR_148728.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171

    3. NR_148729.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171

    4. NR_148730.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171

    5. NR_148731.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22089150..22104911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716381.4 → XP_006716444.1  FHF complex subunit HOOK-interacting protein 2B isoform X1

      Conserved Domains (1) summary
      pfam10257
      Location:79 → 476
      RAI16-like; Retinoic acid induced 16-like protein

    2. XM_005273602.5 → XP_005273659.1  FHF complex subunit HOOK-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_005273659.1

      Conserved Domains (1) summary
      pfam10257
      Location:79 → 476
      RAI16-like; Retinoic acid induced 16-like protein

    RNA

    1. XR_007060751.1 RNA Sequence

    2. XR_428314.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22363108..22378867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361015.1 → XP_054216990.1  FHF complex subunit HOOK-interacting protein 2B isoform X1

    2. XM_054361016.1 → XP_054216991.1  FHF complex subunit HOOK-interacting protein 2B isoform X2

    RNA

    1. XR_008487870.1 RNA Sequence

    2. XR_008487871.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86V87.2 GenPept UniProtKB/Swiss-Prot:Q86V87

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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