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    EFCAB6 EF-hand calcium binding domain 6 [ Homo sapiens (human) ]

    Gene ID: 64800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EFCAB6provided by HGNC
    Official Full Name
    EF-hand calcium binding domain 6provided by HGNC
    Primary source
    HGNC:HGNC:24204
    See related
    Ensembl:ENSG00000186976 MIM:619664; AllianceGenome:HGNC:24204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJBP; HSCBCIP1; dJ185D5.1
    Summary
    This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Biased expression in testis (RPKM 13.3) and thyroid (RPKM 1.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See EFCAB6 in Genome Data Viewer
    Location:
    22q13.2-q13.31
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43528778..43812305, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (44011227..44295198, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43924658..44208185, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43823805-43824306 Neighboring gene MPRA-validated peak4505 silencer Neighboring gene metallophosphoesterase domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43860857-43861358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43883063-43883836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43883837-43884610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43910482-43911240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:43923573-43924072 Neighboring gene EFCAB6 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr22:43932755-43933256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43938541-43939320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43939321-43940098 Neighboring gene uncharacterized LOC101927474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43966769-43967269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44030735-44031236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44039364-44039864 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:44047371-44047871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44054653-44055349 Neighboring gene YWHAQ pseudogene 2 Neighboring gene uncharacterized LOC124905130 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44101993-44102658 Neighboring gene ribosomal protein L4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44208791-44209592 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:44207707-44207948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44215896-44216537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44223866-44224628 Neighboring gene EFCAB6 divergent transcript Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44240991-44241816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44247635-44248134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44256209-44256708 Neighboring gene sulfotransferase family 4A member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Niki T, et al. Mol Cancer Res, 2003 Feb. PMID 12612053
    2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. Hirosawa M, et al. DNA Res, 2001 Feb 28. PMID 11258795
    3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Collins JE, et al. Genome Res, 2003 Jan. PMID 12529303, Free PMC Article
    4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. PLoS Genet, 2013. PMID 23382691, Free PMC Article
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    2. androgen receptor is positively regulated by DJ-1, which antagonizes the function of negative regulators, including DJBP, a novel DJ-1-binding protein
      Title: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23588, KIAA1672

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axonemal A tubule inner sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 6
    Names
    CAP-binding protein complex-interacting protein 1
    DJ-1-binding protein
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030019.1 RefSeqGene

      Range
      5033..288560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022785.4 → NP_073622.2  EF-hand calcium-binding domain-containing protein 6 isoform a

      See identical proteins and their annotated locations for NP_073622.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK058069, AK292411, BC039315, BP325901
      Consensus CDS
      CCDS14049.1
      UniProtKB/Swiss-Prot
      A8K8P6, A8K8Y3, B0QYI4, B0QYI6, Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5
      UniProtKB/TrEMBL
      A0A384ME20
      Related
      ENSP00000262726.7, ENST00000262726.12
      Conserved Domains (4) summary
      COG5126
      Location:294 → 469
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam08976
      Location:1160 → 1260
      EF-hand_11; EF-hand domain
      pfam13499
      Location:1439 → 1499
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:408 → 468
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_198856.3 → NP_942153.1  EF-hand calcium-binding domain-containing protein 6 isoform b

      See identical proteins and their annotated locations for NP_942153.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK058069, AK292411, BC039315, BP325901
      Consensus CDS
      CCDS14050.1
      UniProtKB/TrEMBL
      A0A384ME20
      Related
      ENSP00000379533.2, ENST00000396231.6
      Conserved Domains (4) summary
      COG5126
      Location:142 → 317
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam08976
      Location:1008 → 1108
      EF-hand_11; EF-hand domain
      pfam13499
      Location:1287 → 1347
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:256 → 316
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      43528778..43812305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441462.1 → XP_047297418.1  EF-hand calcium-binding domain-containing protein 6 isoform X9

      UniProtKB/TrEMBL
      A0A384ME20

    2. XM_011530319.4 → XP_011528621.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

      See identical proteins and their annotated locations for XP_011528621.1

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (4) summary
      COG5126
      Location:188 → 363
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam08976
      Location:1054 → 1154
      EF-hand_11; EF-hand domain
      pfam13499
      Location:71 → 129
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:302 → 362
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_011530317.4 → XP_011528619.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011528619.1

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (5) summary
      COG5126
      Location:294 → 469
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:408 → 468
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:1160 → 1260
      EF-hand_11; EF-hand domain
      pfam13499
      Location:177 → 235
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:177 → 235
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_011530321.4 → XP_011528623.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

      See identical proteins and their annotated locations for XP_011528623.1

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (4) summary
      pfam08976
      Location:1008 → 1108
      EF-hand_11; EF-hand domain
      pfam13499
      Location:704 → 758
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:256 → 316
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl25352
      Location:142 → 317
      EFh_PEF; The penta-EF hand (PEF) family

    5. XM_047441461.1 → XP_047297417.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

      UniProtKB/TrEMBL
      A0A384ME20

    6. XM_005261704.3 → XP_005261761.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

      See identical proteins and their annotated locations for XP_005261761.1

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (5) summary
      COG5126
      Location:294 → 469
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:408 → 468
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:1160 → 1260
      EF-hand_11; EF-hand domain
      pfam13499
      Location:177 → 235
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:177 → 235
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    7. XM_011530318.4 → XP_011528620.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (5) summary
      COG5126
      Location:268 → 443
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:382 → 442
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:1134 → 1234
      EF-hand_11; EF-hand domain
      pfam13499
      Location:101 → 171
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:151 → 209
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    8. XM_017028911.3 → XP_016884400.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A384ME20

    9. XM_017028910.3 → XP_016884399.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (5) summary
      COG5126
      Location:320 → 495
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:434 → 494
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:1186 → 1286
      EF-hand_11; EF-hand domain
      pfam13499
      Location:203 → 261
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    10. XM_011530316.2 → XP_011528618.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (5) summary
      COG5126
      Location:320 → 495
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:434 → 494
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:1186 → 1286
      EF-hand_11; EF-hand domain
      pfam13499
      Location:203 → 261
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    11. XM_011530325.3 → XP_011528627.1  EF-hand calcium-binding domain-containing protein 6 isoform X10

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (4) summary
      COG5126
      Location:46 → 221
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:160 → 220
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:912 → 1012
      EF-hand_11; EF-hand domain
      cl08302
      Location:937 → 990
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    12. XM_011530323.3 → XP_011528625.1  EF-hand calcium-binding domain-containing protein 6 isoform X8

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (4) summary
      COG5126
      Location:140 → 315
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam08976
      Location:1006 → 1106
      EF-hand_11; EF-hand domain
      pfam13499
      Location:23 → 81
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:254 → 314
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    13. XM_011530327.3 → XP_011528629.1  EF-hand calcium-binding domain-containing protein 6 isoform X12

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (4) summary
      COG5126
      Location:655 → 801
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:100 → 160
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam08976
      Location:852 → 952
      EF-hand_11; EF-hand domain
      cl08302
      Location:877 → 930
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    14. XM_047441464.1 → XP_047297420.1  EF-hand calcium-binding domain-containing protein 6 isoform X15

    15. XM_011530320.4 → XP_011528622.1  EF-hand calcium-binding domain-containing protein 6 isoform X6

      UniProtKB/TrEMBL
      A0A384ME20
      Conserved Domains (4) summary
      COG5126
      Location:320 → 495
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam08976
      Location:1186 → 1286
      EF-hand_11; EF-hand domain
      pfam13499
      Location:203 → 261
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:434 → 494
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    16. XM_011530326.4 → XP_011528628.1  EF-hand calcium-binding domain-containing protein 6 isoform X11

      Conserved Domains (4) summary
      COG5126
      Location:320 → 495
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam08976
      Location:1186 → 1242
      EF-hand_11; EF-hand domain
      pfam13499
      Location:203 → 261
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:434 → 494
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    17. XM_011530328.4 → XP_011528630.1  EF-hand calcium-binding domain-containing protein 6 isoform X13

      Conserved Domains (3) summary
      COG5126
      Location:320 → 495
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13499
      Location:203 → 261
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:434 → 494
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    18. XM_011530330.4 → XP_011528632.1  EF-hand calcium-binding domain-containing protein 6 isoform X16

      Conserved Domains (3) summary
      COG5126
      Location:320 → 495
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13499
      Location:203 → 261
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:434 → 494
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    19. XM_047441463.1 → XP_047297419.1  EF-hand calcium-binding domain-containing protein 6 isoform X14

    20. XM_047441465.1 → XP_047297421.1  EF-hand calcium-binding domain-containing protein 6 isoform X17

    RNA

    1. XR_007067980.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      44011227..44295198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325843.1 → XP_054181818.1  EF-hand calcium-binding domain-containing protein 6 isoform X9

      UniProtKB/TrEMBL
      A0A384ME20

    2. XM_054325838.1 → XP_054181813.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

      UniProtKB/TrEMBL
      A0A384ME20

    3. XM_054325834.1 → XP_054181809.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A384ME20

    4. XM_054325840.1 → XP_054181815.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

      UniProtKB/TrEMBL
      A0A384ME20

    5. XM_054325841.1 → XP_054181816.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

      UniProtKB/TrEMBL
      A0A384ME20

    6. XM_054325835.1 → XP_054181810.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A384ME20

    7. XM_054325836.1 → XP_054181811.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A384ME20

    8. XM_054325837.1 → XP_054181812.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A384ME20

    9. XM_054325832.1 → XP_054181807.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A384ME20

    10. XM_054325833.1 → XP_054181808.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A384ME20

    11. XM_054325844.1 → XP_054181819.1  EF-hand calcium-binding domain-containing protein 6 isoform X10

      UniProtKB/TrEMBL
      A0A384ME20

    12. XM_054325842.1 → XP_054181817.1  EF-hand calcium-binding domain-containing protein 6 isoform X8

      UniProtKB/TrEMBL
      A0A384ME20

    13. XM_054325846.1 → XP_054181821.1  EF-hand calcium-binding domain-containing protein 6 isoform X12

      UniProtKB/TrEMBL
      A0A384ME20

    14. XM_054325849.1 → XP_054181824.1  EF-hand calcium-binding domain-containing protein 6 isoform X15

    15. XM_054325839.1 → XP_054181814.1  EF-hand calcium-binding domain-containing protein 6 isoform X6

      UniProtKB/TrEMBL
      A0A384ME20

    16. XM_054325845.1 → XP_054181820.1  EF-hand calcium-binding domain-containing protein 6 isoform X11

    17. XM_054325847.1 → XP_054181822.1  EF-hand calcium-binding domain-containing protein 6 isoform X13

    18. XM_054325850.1 → XP_054181825.1  EF-hand calcium-binding domain-containing protein 6 isoform X16

    19. XM_054325848.1 → XP_054181823.1  EF-hand calcium-binding domain-containing protein 6 isoform X14

    20. XM_054325851.1 → XP_054181826.1  EF-hand calcium-binding domain-containing protein 6 isoform X17

    RNA

    1. XR_008485410.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5THR3.1 GenPept UniProtKB/Swiss-Prot:Q5THR3

    Gene LinkOut

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