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    ZNF366 zinc finger protein 366 [ Homo sapiens (human) ]

    Gene ID: 167465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZNF366provided by HGNC
    Official Full Name
    zinc finger protein 366provided by HGNC
    Primary source
    HGNC:HGNC:18316
    See related
    Ensembl:ENSG00000178175 MIM:610159; AllianceGenome:HGNC:18316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCSCRIPT; DC-SCRIPT
    Summary
    Enables nuclear estrogen receptor binding activity and transcription corepressor activity. Involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta (RPKM 4.6), fat (RPKM 4.5) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF366 in Genome Data Viewer
    Location:
    5q13.2; 5q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (72439903..72507410, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (72921070..72988558, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71735730..71803237, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16080 Neighboring gene ribosomal protein L10a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16081 Neighboring gene Y-box binding protein 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22651 Neighboring gene Sharpr-MPRA regulatory region 3669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16082 Neighboring gene uncharacterized LOC102503427 Neighboring gene TNPO1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:71930309-71930809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72004631-72005132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72005133-72005632 Neighboring gene ribosomal protein L7 pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation. Ansems M, et al. Biochim Biophys Acta, 2010 Dec. PMID 20478364
    2. Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study. Sieuwerts AM, et al. Breast Cancer Res, 2010. PMID 21122099, Free PMC Article
    3. Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators. Triantis V, et al. J Immunol, 2006 Jan 15. PMID 16393996
    4. DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells. Ansems M, et al. Prostate, 2012 Dec 1. PMID 22473304
    5. DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation. Søndergaard JN, et al. J Immunol, 2015 Aug 15. PMID 26170389

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-kappaBp65 after TLR activation in human DCs.
      Title: DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation.
    2. these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells.
      Title: DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.
    3. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ.
      Title: DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.
    4. DC-SCRIPT is a key regulator of androgen receptor and vitamin d receptor that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer.
      Title: DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells.
    5. DC-SCRIPT has a primary role in the regulation of interleukin (IL)-10 production by monocytes.
      Title: Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.
    6. study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors
      Title: Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study.
    7. DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review]
      Title: Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
      Title: Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.
    10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association with bone mass and geometry in the Framingham Heart Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: MRPS27

    Homology

    Clone Names

    • FLJ33375, FLJ39796

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear estrogen receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear estrogen receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to estrogen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 366
    Names
    dendritic cell-specific transcript protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152625.3 → NP_689838.1  zinc finger protein 366

      See identical proteins and their annotated locations for NP_689838.1

      Status: VALIDATED

      Source sequence(s)
      AC093278, AK097115, BK000210
      Consensus CDS
      CCDS4015.1
      UniProtKB/Swiss-Prot
      Q5HYI9, Q7RTV4, Q8N895
      UniProtKB/TrEMBL
      Q0VAH5
      Related
      ENSP00000313158.5, ENST00000318442.6
      Conserved Domains (2) summary
      COG5048
      Location:253 → 549
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      72439903..72507410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      72921070..72988558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N895.1 GenPept UniProtKB/Swiss-Prot:Q8N895

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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