HOPX HOP homeobox [Homo sapiens (human)] - Gene

Summary

Official Symbol: HOPXprovided by HGNC
Official Full Name: HOP homeoboxprovided by HGNC
Primary source: HGNC:HGNC:24961
See related: Ensembl:ENSG00000171476 MIM:607275; AllianceGenome:HGNC:24961
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HOD; HOP; OB1; LAGY; TOTO; CAMEO; NECC1; SMAP31
Summary: The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Expression: Biased expression in skin (RPKM 80.6), esophagus (RPKM 62.3) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (56647998..56681706, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (60135864..60169690, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (57514164..57547462, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8[+] T cell expansion.
Title: Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8(+) T cell expansion.
HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.
Title: HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.
HOPX Exhibits Oncogenic Activity during Squamous Skin Carcinogenesis.
Title: HOPX Exhibits Oncogenic Activity during Squamous Skin Carcinogenesis.
Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
Title: Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways.
Title: HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways.
Study revealed that ZNF750 is both necessary and sufficient for HOPX induction and propose that HOPX functions as a positive regulator of epidermal late differentiation within a p63-ZNF750-HOPX pathway to up-regulate the key proteins required for terminal epidermal differentiation, providing clarity to previous studies showing conflicting results.
Title: HOPX Is a ZNF750 Target that Promotes Late Epidermal Differentiation.
These data indicated that miR421 may act as an oncogene through the effects of HOPX on the Wnt/bcatenin signaling pathway and may provide insight into the mechanisms underlying carcinogenesis and the identification of potential biomarkers associated with nonsmall cell lung cancer (NSCLC).
Title: ΜicroRNA‑421 promotes the progression of non‑small cell lung cancer by targeting HOPX and regulating the Wnt/β‑catenin signaling pathway.
In idiopathic pulmonary fibrosis lungs, HOPX expression was decreased in whole lungs and significantly correlated to a decline in lung function and progression of IPF. HOPX is upregulated during early alveolar injury and repair process in the lung. Decreased HOPX expression might contribute to failed regenerative processes in end-stage IPF lungs.
Title: Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis.
The hypertrophic signaling is not effectively activated during monolayer-based cardiac differentiation, thereby preventing expression of HOPX and its activation of downstream genes that govern late stages of cardiomyocyte maturation.
Title: Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.
In the present study, we compared the 2 potential epigenetic prognostic markers of CDO1 hypermethylation and HOPX hypermethylation using the same breast cancer samples, and the final focus was given on CDO1 hypermethylation
Title: Differential Prognostic Relevance of Promoter DNA Methylation of CDO1 and HOPX in Primary Breast Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G34373 (e-PCR)
- UniSTS:20507

GDB:313261 (e-PCR)
- UniSTS:156445

A006J04 (e-PCR)
- UniSTS:23337

D10S2448 (e-PCR)
- UniSTS:474444

RH17813 (e-PCR)
- UniSTS:30557

D1S1423 (e-PCR)
- UniSTS:149619

D11S3114 (e-PCR)
- UniSTS:152207

D4S2787 (e-PCR)
- UniSTS:65720

G32360 (e-PCR)
- UniSTS:116951

GDB:631802 (e-PCR)
- UniSTS:158429

D4S2900 (e-PCR)
- UniSTS:79088

A006D37 (e-PCR)
- UniSTS:13043

G20731 (e-PCR)
- UniSTS:13044

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bundle of His development	NAS Non-traceable Author Statement more info	PubMed
involved_in chaperone-mediated protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gap junction assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within trophectodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeodomain-only protein

Names: lung cancer-associated Y protein; not expressed in choriocarcinoma clone 1; odd homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050687.1 RefSeqGene

Range

5411..38709

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145459.2 → NP_001138931.1 homeodomain-only protein isoform b

See identical proteins and their annotated locations for NP_001138931.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AB059410, CB996541, DB180848

Consensus CDS

CCDS3507.1

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Related

ENSP00000370654.3, ENST00000381255.7

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001145460.2 → NP_001138932.1 homeodomain-only protein isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) includes an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a.

Source sequence(s)

AB059408, AF492679, CK002567, DA512059

Consensus CDS

CCDS54767.1

UniProtKB/Swiss-Prot

Q9BPY8

Related

ENSP00000450527.1, ENST00000554144.5

Conserved Domains (1) summary

cd00086
Location:28 → 66

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_032495.6 → NP_115884.4 homeodomain-only protein isoform a

See identical proteins and their annotated locations for NP_115884.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AB059408, DA512059

Consensus CDS

CCDS47062.1

UniProtKB/Swiss-Prot

Q9BPY8

Related

ENSP00000396275.1, ENST00000420433.6

Conserved Domains (1) summary

cd00086
Location:28 → 80

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_139211.5 → NP_631957.1 homeodomain-only protein isoform b

See identical proteins and their annotated locations for NP_631957.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AB059410, DB180848

Consensus CDS

CCDS3507.1

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Related

ENSP00000315198.7, ENST00000317745.11

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_139212.4 → NP_631958.1 homeodomain-only protein isoform b

See identical proteins and their annotated locations for NP_631958.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AF454763, AK289707

Consensus CDS

CCDS3507.1

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Related

ENSP00000337330.7, ENST00000337881.12

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

56647998..56681706 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008728.2 → XP_016864217.1 homeodomain-only protein isoform X1

Conserved Domains (1) summary

cd00086
Location:25 → 77

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_017008732.2 → XP_016864221.1 homeodomain-only protein isoform X4

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Related

ENSP00000451794.1, ENST00000556376.6

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_047416319.1 → XP_047272275.1 homeodomain-only protein isoform X3

Conserved Domains (1) summary

cd00086
Location:28 → 80

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_047416322.1 → XP_047272278.1 homeodomain-only protein isoform X4

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8
XM_047416320.1 → XP_047272276.1 homeodomain-only protein isoform X3

Conserved Domains (1) summary

cd00086
Location:28 → 80

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_047416321.1 → XP_047272277.1 homeodomain-only protein isoform X3

Conserved Domains (1) summary

cd00086
Location:28 → 80

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_017008729.3 → XP_016864218.2 homeodomain-only protein isoform X2

Conserved Domains (1) summary

cd00086
Location:48 → 100

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_017008730.3 → XP_016864219.1 homeodomain-only protein isoform X4

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_017008734.2 → XP_016864223.1 homeodomain-only protein isoform X4

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Related

ENSP00000452340.1, ENST00000553379.6

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_017008731.3 → XP_016864220.1 homeodomain-only protein isoform X4

UniProtKB/Swiss-Prot

A8K0Z2, E9PB55, G3V294, Q8N0V6, Q96CI1, Q9BPY8

Related

ENSP00000452098.1, ENST00000555760.6

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.