Envelope surface glycoprotein gp120
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env
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SDF-1alpha and HIV-1 gp120 induce the appearance of pseudopodia in which CD26 and CXCR4 co-localize |
PubMed
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env
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Infection of cells with Macrophage-tropic HIV-1 confers preferential survival to cells with low CD26 levels; the third hypervariable region (V3) of the HIV-1 gp120 envelope protein plays an important role in this selection process |
PubMed
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env
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Although CD26 has been described as a cofactor for HIV-1 gp120 mediated entry into cells, no evidence of a CD26-gp120 interaction was observed in vitro by using glutathione S-transferase-tagged HIV-1 gp120 |
PubMed
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env
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Apoptosis is observed in CD4+ cells expressing the HIV-1 gp120/gp41 complex and with enhanced levels of CD26, but is not detected in cell lines expressing an uncleavable precursor of HIV-1 gp160 |
PubMed
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env
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CD26 (dipeptidyl peptidase IV) cleaves the highly conserved V3 loop of HIV-1 gp120 and functions as a cofactor for entry of HIV-1 in CD4+ human cells; coexpression of human CD4 and CD26 in murine NIH 3T3 cells renders them permissive to HIV-1 |
PubMed
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env
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HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 |
PubMed
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env
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Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC |
PubMed
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Envelope transmembrane glycoprotein gp41
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env
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Apoptosis is observed in CD4+ cells expressing the HIV-1 gp120/gp41 complex and with enhanced levels of CD26, but is not detected in cell lines expressing an uncleavable precursor of HIV-1 gp160 |
PubMed
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Tat
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tat
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Microarray analysis indicates HIV-1 Tat-induced upregulation of dipeptidylpeptidase 4 (DPP4; CD26; adenosine deaminase complexing protein 2) in primary human brain microvascular endothelial cells |
PubMed
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tat
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HIV-1 Tat induces tyrosine phosphorylation of DPPIV in Tat/DPPIV-coexpressing cells |
PubMed
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tat
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HIV1-Tat co-localizes and coimmunoprecipitates with human Dipeptidyl peptidase IV (DPPIV) protein |
PubMed
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tat
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The N-terminal nine amino acids of HIV-1 Tat mediate the binding of Tat to CD26 |
PubMed
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tat
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HIV-1 Tat inhibits the enzymatic activity of CD26, thereby suppressing DNA synthesis and IL-1 beta production, stimulating secretion of IL-1 receptor antagonist and TNF-alpha, and causing, at least in part, the immunosuppressive effects of Tat |
PubMed
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