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    FABP5 fatty acid binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 2171, updated on 10-Dec-2024

    Summary

    Official Symbol
    FABP5provided by HGNC
    Official Full Name
    fatty acid binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:3560
    See related
    Ensembl:ENSG00000164687 MIM:605168; AllianceGenome:HGNC:3560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EFABP; KFABP; E-FABP; PAFABP; PA-FABP
    Summary
    This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]
    Expression
    Biased expression in esophagus (RPKM 725.7), fat (RPKM 171.7) and 11 other tissues See more
    Orthologs
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    Genomic context

    See FABP5 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (81280536..81284775)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (81712114..81716359)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (82192771..82197010)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19327 Neighboring gene NANOG hESC enhancer GRCh37_chr8:82108601-82109175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27580 Neighboring gene ubiquitin conjugating enzyme E2 H pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:82192414-82193248 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:82193249-82194083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27582 Neighboring gene lncRNA associated with lymph node metastasis in cervical cancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:82243330-82243830 Neighboring gene uncharacterized LOC105375925 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:82262688-82263887 Neighboring gene uncharacterized LOC105375926

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (47 hits/1137 screens)

    EBI GWAS Catalog

    Description
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding  
    enables fatty acid binding PubMed 
    enables identical protein binding PubMed 
    enables lipid binding PubMed 
    enables long-chain fatty acid transmembrane transporter activity PubMed 
    enables protein binding PubMed 
    enables retinoic acid binding  
    Process Evidence Code Pubs
    involved_in epidermis development PubMed 
    involved_in fatty acid transport  
    involved_in glucose homeostasis  
    involved_in glucose metabolic process  
    involved_in lipid metabolic process PubMed 
    involved_in lipid transport across blood-brain barrier PubMed 
    involved_in long-chain fatty acid transport PubMed 
    involved_in negative regulation of D-glucose transmembrane transport  
    involved_in phosphatidylcholine biosynthetic process  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway  
    involved_in regulation of prostaglandin biosynthetic process  
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid  
    involved_in regulation of sensory perception of pain  
    involved_in retrograde trans-synaptic signaling by endocannabinoid  
    Component Evidence Code Pubs
    located_in azurophil granule lumen  
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol  
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    located_in glutamatergic synapse  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in plasma membrane  
    located_in postsynaptic cytosol  
    located_in postsynaptic density  
    located_in postsynaptic density, intracellular component  
    located_in secretory granule membrane  
    located_in synapse  

    General protein information

    Preferred Names
    fatty acid-binding protein 5
    Names
    epidermal-type fatty acid-binding protein
    fatty acid binding protein 5 (psoriasis-associated)
    psoriasis-associated fatty acid-binding protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028154.1 RefSeqGene

      Range
      5054..9293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001444.3 → NP_001435.1  fatty acid-binding protein 5

      See identical proteins and their annotated locations for NP_001435.1

      Status: REVIEWED

      Source sequence(s)
      AK226036
      Consensus CDS
      CCDS6228.1
      UniProtKB/Swiss-Prot
      B2R4K0, Q01469
      UniProtKB/TrEMBL
      E7DVW5
      Related
      ENSP00000297258.6, ENST00000297258.11
      Conserved Domains (1) summary
      cd19468
      Location:6 → 133
      FABP5; fatty acid binding protein 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      81280536..81284775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      81712114..81716359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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