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    GPR62 G protein-coupled receptor 62 [ Homo sapiens (human) ]

    Gene ID: 118442, updated on 27-Nov-2024

    Summary

    Official Symbol
    GPR62provided by HGNC
    Official Full Name
    G protein-coupled receptor 62provided by HGNC
    Primary source
    HGNC:HGNC:13301
    See related
    Ensembl:ENSG00000180929 MIM:606917; AllianceGenome:HGNC:13301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR8; KPG_005
    Summary
    Enables arrestin family protein binding activity. Involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of calcium-mediated signaling. Located in endosome and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPR62 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51955381..51957499)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51988300..51990418)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51989397..51991515)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51975282-51975930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19921 Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51990057-51990645 Neighboring gene poly(rC) binding protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51999749-52000312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52000313-52000874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52002001-52002564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52002565-52003126 Neighboring gene abhydrolase domain containing 14B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52007254-52008190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14424 Neighboring gene ABHD14A-ACY1 readthrough Neighboring gene Sharpr-MPRA regulatory region 207 Neighboring gene abhydrolase domain containing 14A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52015181-52015682

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC26943

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arrestin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G-protein coupled receptor 62
    Names
    G-protein coupled receptor GPCR8
    G-protein coupled receptor KPG_005
    hGPCR8
    probable G-protein coupled receptor 62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080865.4NP_543141.3  G-protein coupled receptor 62

      See identical proteins and their annotated locations for NP_543141.3

      Status: VALIDATED

      Source sequence(s)
      AC115284, BC026357
      Consensus CDS
      CCDS2838.1
      UniProtKB/Swiss-Prot
      F1DAM4, Q5KU27, Q9BZJ7
      UniProtKB/TrEMBL
      Q8TAM0
      Related
      ENSP00000319250.4, ENST00000322241.6
      Conserved Domains (1) summary
      pfam00001
      Location:31290
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      51955381..51957499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      51988300..51990418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)