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    NEURL4 neuralized E3 ubiquitin protein ligase 4 [ Homo sapiens (human) ]

    Gene ID: 84461, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NEURL4provided by HGNC
    Official Full Name
    neuralized E3 ubiquitin protein ligase 4provided by HGNC
    Primary source
    HGNC:HGNC:34410
    See related
    Ensembl:ENSG00000215041 MIM:615865; AllianceGenome:HGNC:34410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NEURL4 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7315628..7329335, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7219612..7233319, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7218947..7232654, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:7209261-7210072 and GRCh37_chr17:7210073-7210883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11610 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8107 Neighboring gene G protein pathway suppressor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7226660-7227166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7227167-7227672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7231927-7232586 Neighboring gene Sharpr-MPRA regulatory region 1992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7239291-7240052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7240053-7240814 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258016-7258542 Neighboring gene potassium channel tetramerization domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome. Loukil A, et al. J Cell Biol, 2017 May 1. PMID 28385950, Free PMC Article
    2. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Cardamone MD, et al. J Cell Biol, 2022 Mar 7. PMID 35157000, Free PMC Article
    3. NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization. Cubillos-Rojas M, et al. Oncotarget, 2017 Sep 22. PMID 28977907, Free PMC Article
    4. Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2. García-Cano J, et al. Mol Oncol, 2020 Jan. PMID 31665549, Free PMC Article
    5. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. Li J, et al. EMBO Rep, 2012 Jun 1. PMID 22441691, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.
      Title: Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.
    2. The data support a model in which the daughter centriole promotes ciliogenesis through Neurl-4-dependent regulation of CP110 levels at the mother centriole.
      Title: The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.
    3. the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture
      Title: Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.
    4. Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres
      Title: Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: GPS2

    Homology

    Clone Names

    • FLJ35680, KIAA1787

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuralized-like protein 4
    Names
    neuralized homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005408.2 → NP_001005408.1  neuralized-like protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame 6-nt segment in the coding region, as compared to variant 1. The encoded isoform 2 is thus slightly shorter than isoform 1.
      Source sequence(s)
      AB058690, AC026954, AL136870
      Consensus CDS
      CCDS42252.1
      UniProtKB/TrEMBL
      I3L2W2
      Related
      ENSP00000319826.7, ENST00000315614.11
      Conserved Domains (2) summary
      smart00588
      Location:316 → 437
      NEUZ; domain in neuralized proteins
      cd12887
      Location:718 → 880
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    2. NM_032442.3 → NP_115818.2  neuralized-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_115818.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB058690, AC026954, AL136870
      Consensus CDS
      CCDS42251.1
      UniProtKB/Swiss-Prot
      Q6GPI8, Q96IU9, Q96JN8, Q9H0B0
      UniProtKB/TrEMBL
      I3L2W2
      Related
      ENSP00000382390.2, ENST00000399464.7
      Conserved Domains (2) summary
      smart00588
      Location:316 → 437
      NEUZ; domain in neuralized proteins
      cd12887
      Location:523 → 684
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7315628..7329335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160020.1 Reference GRCh38.p14 PATCHES

      Range
      73993..87700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7219612..7233319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96JN8.2 GenPept UniProtKB/Swiss-Prot:Q96JN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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