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    cnd1 condensin complex non-SMC subunit Cnd1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541201, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cnd1
    Official Full Name
    condensin complex non-SMC subunit Cnd1
    Primary source
    PomBase:SPBC776.13
    Locus tag
    SPOM_SPBC776.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cnd1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3200088..3203986)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dbf4(Dfp1)-dependent protein kinase Hsk1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phospholipid--diacylglycerol acyltransferase Plh1 Neighboring gene dihydrolipoyllysine-residue succinyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1. Schiklenk C, et al. J Cell Biol, 2018 Jul 2. PMID 29735745, Free PMC Article
    2. RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast. Nakazawa N, et al. Genes Cells, 2015 Jun. PMID 25847133, Free PMC Article
    3. ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding. Akai Y, et al. Open Biol, 2014 Dec. PMID 25520186, Free PMC Article
    4. Establishment of dsDNA-dsDNA interactions by the condensin complex. Tang M, et al. Mol Cell, 2023 Nov 2. PMID 37820734, Free PMC Article
    5. Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4. Sutani T, et al. Genes Dev, 1999 Sep 1. PMID 10485849, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we identify the C2H2 zinc-finger transcription factor Zas1 as a key regulator of mitotic condensation dynamics in a quantitative live-cell microscopy screen of the fission yeast Schizosaccharomyces pombe By binding to specific DNA target sequences in their promoter regions, Zas1 controls expression of the Cnd1 subunit of the condensin protein complex and several other target genes
      Title: Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.
    2. Study reports isolation and characterization of 21 fission yeast mutants for three non-SMC subunits, created using error-prone mutagenesis that resulted in single-amino acid substitutions; Three cnd1 and three cnd3 mutants increased cell size and doubled DNA content, thereby eliminating the haploid state implicating Cnd1 and Cnd3 in ploidy maintenance.
      Title: Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA-DNA tethering activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables double-stranded DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to topological DNA co-entrapment activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolar peripheral inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    condensin complex non-SMC subunit Cnd1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3200088..3203986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022250.3 → NP_596329.1  condensin complex non-SMC subunit Cnd1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596329.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94679
      Conserved Domains (4) summary
      COG5098
      Location:9 → 1158
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12717
      Location:974 → 1142
      Cnd1; non-SMC mitotic condensation complex subunit 1
      pfam12922
      Location:72 → 232
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
      sd00044
      Location:309 → 342
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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