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    spc7 outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539155, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spc7
    Official Full Name
    outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7
    Primary source
    PomBase:SPCC1020.02
    Locus tag
    SPOM_SPCC1020.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See spc7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (786289..790660, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase subunit Rpb6 Neighboring gene mitochondrial iron ion transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins. Jakopec V, et al. Mol Cell Biol, 2012 Aug. PMID 22711988, Free PMC Article
    2. Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I. Miyazaki S, et al. Cold Spring Harb Symp Quant Biol, 2017. PMID 29196561
    3. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components. Yamagishi Y, et al. Nat Cell Biol, 2012 Jun 3. PMID 22660415
    4. Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors. Meadows JC, et al. Dev Cell, 2011 Jun 14. PMID 21664573, Free PMC Article
    5. Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I. Miyazaki S, et al. Genes Cells, 2017 Jun. PMID 28497540

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit spindle assembly checkpoint proteins and promote chromosome alignment.
      Title: MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.
    2. Spc7 interacts genetically with the Mal2-containing Sim4 complex.
      Title: The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.
    3. spc7 can suppress the mal3 mutant phenotype. Spc7, an essential component of the kinetochore that associates with the central centromere region, interacts with the microtubule plus-end-associated protein Mal3 at the microtubule-kinetochore interface.
      Title: The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables kinetochore adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule plus-end binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deactivation of mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome orientation in meiotic metaphase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic centromeric cohesion protection in anaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid biorientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiosis I spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Knl1/Spc105 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      786289..790660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022949.3 → NP_587958.1  outer kinetochore KNL network protein, KNL-1 family member, blinkin, Spc7 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587958.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59757
      Conserved Domains (4) summary
      smart00787
      Location:873 → 1189
      Spc7; Spc7 kinetochore protein
      pfam02050
      Location:1042 → 1142
      FliJ; Flagellar FliJ protein
      pfam15402
      Location:102 → 599
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam15577
      Location:1239 → 1300
      Spc7_C2; Spc7_C2
    Nucleotide Protein
    Heading Accession and Version

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