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    mhf1 protein mhf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540443, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mhf1
    Official Full Name
    protein mhf1
    Primary source
    PomBase:SPBC2D10.16
    Locus tag
    SPOM_SPBC2D10.16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mhf1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2996345..2997147)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene myosin type V Neighboring gene ncRNA Neighboring gene peptidyl-tRNA hydrolase Pth1 Neighboring gene SHREC complex intermodule linker subunit Clr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC1 kinase family ubiquinone biosynthesis ATPase Coq8 Neighboring gene ribosome biogenesis protein Alb1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast kinetochore complex Mhf1-Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation. Jian Y, et al. J Cell Sci, 2023 Jan 15. PMID 36537249
    2. The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast. Wong IN, et al. Elife, 2019 Dec 19. PMID 31855181, Free PMC Article
    3. Regulation of mitotic recombination between DNA repeats in centromeres. Zafar F, et al. Nucleic Acids Res, 2017 Nov 2. PMID 28977643, Free PMC Article
    4. Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly. Dong Q, et al. Proc Natl Acad Sci U S A, 2021 Nov 30. PMID 34810257, Free PMC Article
    5. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Yan Z, et al. Mol Cell, 2010 Mar 26. PMID 20347428, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fission yeast kinetochore complex Mhf1-Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation.
      Title: The fission yeast kinetochore complex Mhf1-Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation.
    2. we confirm that Fml1 does indeed suppress IFSA, and show that this function depends on its catalytic activity and ability to interact with Mhf1-Mhf2 via its C-terminal domain.
      Title: The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via synthesis-dependent strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CENP-T-W-S-X complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FANCM-MHF complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein mhf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2996345..2997147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022155.4 → NP_596235.2  protein mhf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596235.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74807
      Conserved Domains (1) summary
      pfam15630
      Location:5 → 86
      CENP-S; Kinetochore component CENP-S
    Nucleotide Protein
    Heading Accession and Version

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