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    ubc7 ubiquitin-conjugating enzyme Ubc7 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541252, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ubc7
    Official Full Name
    ubiquitin-conjugating enzyme Ubc7
    Primary source
    PomBase:SPBP16F5.04
    Locus tag
    SPOM_SPBP16F5.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ubcP3
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    Genomic context

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    See ubc7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (1905688..1907025)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene SAGA complex, phosphatidylinositol pseudokinase subunit Tra1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein Yar1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7. Hann ZS, et al. Acta Crystallogr F Struct Biol Commun, 2019 Aug 1. PMID 31397327, Free PMC Article
    2. Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. Hughes BT, et al. J Biol Chem, 2009 Jul 31. PMID 19520858, Free PMC Article
    3. A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis. Le TK, et al. J Cell Sci, 2023 Oct 1. PMID 37694715
    4. A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis. Osaka F, et al. Mol Cell Biol, 1997 Jun. PMID 9154838, Free PMC Article
    5. S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Lv Z, et al. Mol Cell, 2017 Feb 16. PMID 28162934, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner nuclear membrane-associated protein degradation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme Ubc7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1905688..1907025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021678.3 → NP_595778.1  ubiquitin-conjugating enzyme Ubc7 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595778.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O00102, Q9HDP3
      Conserved Domains (2) summary
      COG5078
      Location:1 → 164
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:9 → 160
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version

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