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    ZNF236 zinc finger protein 236 [ Homo sapiens (human) ]

    Gene ID: 7776, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF236provided by HGNC
    Official Full Name
    zinc finger protein 236provided by HGNC
    Primary source
    HGNC:HGNC:13028
    See related
    Ensembl:ENSG00000130856 MIM:604760; AllianceGenome:HGNC:13028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF236A; ZNF236B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glucose stimulus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 5.8), ovary (RPKM 2.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF236 in Genome Data Viewer
    Location:
    18q23
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (76822557..76972901)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (77051329..77214701)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (74534513..74684857)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904327 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:74503764-74503939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9558 Neighboring gene ZNF236 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13513 Neighboring gene RNA, U6 small nuclear 346, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9561 Neighboring gene uncharacterized LOC105372214 Neighboring gene ribosomal protein L26 pseudogene 35 Neighboring gene exportin for tRNA pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74651502-74652002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9562 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74678461-74679129 Neighboring gene uncharacterized LOC105372217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74694849-74695698 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:74700218-74701417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74704741-74705313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74709764-74710264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74710265-74710765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74717425-74718324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74718325-74719223 Neighboring gene myelin basic protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:74748403-74749602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74757338-74757860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74765055-74765555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74766661-74767562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74770546-74771179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13521 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:74776675-74777874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13524 Neighboring gene uncharacterized LOC124904328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74802305-74802806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74802807-74803306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74804211-74804718

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of ZNF236, a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23. Holmes DI, et al. Genomics, 1999 Aug 15. PMID 10458916
    2. The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. Halama N, et al. Genomics, 2003 Sep. PMID 12906866
    3. Identification of glucose-regulated genes in human mesangial cells by mRNA differential display. Holmes DI, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299475
    4. 14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation. Marzinke MA, et al. Arch Biochem Biophys, 2013 Dec. PMID 24161943, Free PMC Article
    5. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. McDonough CW, et al. Hum Genet, 2009 Dec. PMID 19690890, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 236
    Names
    regulated by glucose

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306089.2 → NP_001293018.1  zinc finger protein 236 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC027575, AC093330
      Consensus CDS
      CCDS77201.1
      UniProtKB/TrEMBL
      J9JID5
      Related
      ENSP00000322361.9, ENST00000320610.14
      Conserved Domains (5) summary
      COG5048
      Location:197 → 707
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1255 → 1275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1183 → 1207
      zf-H2C2_2; Zinc-finger double domain

    2. NM_007345.4 → NP_031371.3  zinc finger protein 236 isoform 2

      See identical proteins and their annotated locations for NP_031371.3

      Status: REVIEWED

      Source sequence(s)
      AC027575, AC093330
      Consensus CDS
      CCDS42447.1
      UniProtKB/Swiss-Prot
      B2RTX9, Q9UL36, Q9UL37
      Related
      ENSP00000253159.8, ENST00000253159.12
      Conserved Domains (5) summary
      COG5048
      Location:195 → 705
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:199 → 219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1253 → 1273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:197 → 219
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1181 → 1205
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      76822557..76972901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526168.3 → XP_011524470.1  zinc finger protein 236 isoform X4

      Conserved Domains (5) summary
      COG5048
      Location:197 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1255 → 1275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1183 → 1207
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011526169.4 → XP_011524471.1  zinc finger protein 236 isoform X5

      Conserved Domains (5) summary
      COG5048
      Location:197 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1255 → 1275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1183 → 1207
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011526165.4 → XP_011524467.1  zinc finger protein 236 isoform X1

      See identical proteins and their annotated locations for XP_011524467.1

      UniProtKB/Swiss-Prot
      B2RTX9, Q9UL36, Q9UL37
      Conserved Domains (5) summary
      COG5048
      Location:195 → 705
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:199 → 219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1253 → 1273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:197 → 219
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1181 → 1205
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047437793.1 → XP_047293749.1  zinc finger protein 236 isoform X2

    5. XM_011526166.3 → XP_011524468.1  zinc finger protein 236 isoform X3

      UniProtKB/TrEMBL
      Q59HC5
      Conserved Domains (5) summary
      COG5048
      Location:56 → 566
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1114 → 1134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:58 → 80
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1042 → 1066
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      77051329..77214701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319093.1 → XP_054175068.1  zinc finger protein 236 isoform X6

    2. XM_054319098.1 → XP_054175073.1  zinc finger protein 236 isoform X4

    3. XM_054319099.1 → XP_054175074.1  zinc finger protein 236 isoform X5

    4. XM_054319095.1 → XP_054175070.1  zinc finger protein 236 isoform X1

    5. XM_054319096.1 → XP_054175071.1  zinc finger protein 236 isoform X2

    6. XM_054319094.1 → XP_054175069.1  zinc finger protein 236 isoform X1

    7. XM_054319097.1 → XP_054175072.1  zinc finger protein 236 isoform X3

      UniProtKB/TrEMBL
      Q59HC5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UL36.2 GenPept UniProtKB/Swiss-Prot:Q9UL36

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