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    KRT25 keratin 25 [ Homo sapiens (human) ]

    Gene ID: 147183, updated on 3-Dec-2024

    Summary

    Official Symbol
    KRT25provided by HGNC
    Official Full Name
    keratin 25provided by HGNC
    Primary source
    HGNC:HGNC:30839
    See related
    Ensembl:ENSG00000204897 MIM:616646; AllianceGenome:HGNC:30839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARWH3; KRT25A; KRT24IRS1
    Summary
    This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KRT25 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40748021..40755542, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41612350..41619857, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38904273..38911583, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 24 Neighboring gene keratin 223, pseudogene Neighboring gene keratin 26 Neighboring gene Sharpr-MPRA regulatory region 1152 Neighboring gene keratin 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hair cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hair follicle morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in keratin filament IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 25
    Names
    CK-25
    K25
    K25A
    cytokeratin-25
    keratin 25, type I
    keratin-25A
    type I inner root sheath specific keratin 25 irs1
    type I inner root sheath-specific keratin-K25irs1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012414.1 RefSeqGene

      Range
      5002..12312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181534.4NP_853512.1  keratin, type I cytoskeletal 25

      See identical proteins and their annotated locations for NP_853512.1

      Status: REVIEWED

      Source sequence(s)
      AJ564204, AK129503
      Consensus CDS
      CCDS11373.1
      UniProtKB/Swiss-Prot
      Q7Z3Z0
      UniProtKB/TrEMBL
      Q6ZPD6
      Related
      ENSP00000310573.4, ENST00000312150.5
      Conserved Domains (2) summary
      pfam00038
      Location:78391
      Filament; Intermediate filament protein
      cl02488
      Location:173370
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40748021..40755542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524414.2XP_011522716.1  keratin, type I cytoskeletal 25 isoform X1

      UniProtKB/TrEMBL
      Q6ZPD6
      Conserved Domains (2) summary
      pfam00038
      Location:76389
      Filament; Intermediate filament protein
      cl02488
      Location:171368
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41612350..41619857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315233.1XP_054171208.1  keratin, type I cytoskeletal 25 isoform X1

      UniProtKB/TrEMBL
      Q6ZPD6