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    SPMIP8 sperm microtubule inner protein 8 [ Homo sapiens (human) ]

    Gene ID: 374739, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPMIP8provided by HGNC
    Official Full Name
    sperm microtubule inner protein 8provided by HGNC
    Primary source
    HGNC:HGNC:33745
    See related
    Ensembl:ENSG00000159648 MIM:610264; AllianceGenome:HGNC:33745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEPP
    Summary
    Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and sperm flagellum. Predicted to be active in axonemal A tubule inner sheath. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 1.8), thyroid (RPKM 0.7) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SPMIP8 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57976544..57988116)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63771815..63783405)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58010448..58022020)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene kinesin family member C3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57869467-57869968 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57869969-57870468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57871284-57872020 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57879667-57880550 Neighboring gene RNA, U6 small nuclear 20, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57880551-57881432 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57907038-57907565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57917491-57918038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57918039-57918586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7538 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57945302-57946008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57972707-57973534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57973535-57974362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57998489-57998988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7540 Neighboring gene Sharpr-MPRA regulatory region 3942 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10920 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58046115-58046647 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58046648-58047179 Neighboring gene zinc finger protein 319 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58058267-58058854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58058855-58059440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58059673-58060222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58060773-58061322 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1 Neighboring gene matrix metallopeptidase 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Clone Names

    • MGC129930, MGC129931

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath  
    located_in sperm flagellum  

    General protein information

    Preferred Names
    sperm microtubule inner protein 8
    Names
    testicular tissue protein Li 196
    testis, prostate and placenta expressed
    testis, prostate and placenta-expressed protein
    testis/prostate/placenta-expressed protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199046.3NP_950247.3  sperm microtubule inner protein 8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC010543, HM005509
      Consensus CDS
      CCDS10790.2
      UniProtKB/TrEMBL
      A0A140VJW9
      Related
      ENSP00000290871.6, ENST00000290871.10
    2. NM_199456.3NP_955535.3  sperm microtubule inner protein 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC010543, BC104459, HM005509
      Consensus CDS
      CCDS45496.2
      UniProtKB/Swiss-Prot
      Q6URK7, Q6URK8
      Related
      ENSP00000401917.3, ENST00000441824.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57976544..57988116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434077.1XP_047290033.1  sperm microtubule inner protein 8 isoform X2

    2. XM_047434076.1XP_047290032.1  sperm microtubule inner protein 8 isoform X1

    3. XM_017023218.2XP_016878707.1  sperm microtubule inner protein 8 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63771815..63783405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380278.1XP_054236253.1  sperm microtubule inner protein 8 isoform X1

    2. XM_054380280.1XP_054236255.1  sperm microtubule inner protein 8 isoform X2

    3. XM_054380279.1XP_054236254.1  sperm microtubule inner protein 8 isoform X1

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