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    MYOM3 myomesin 3 [ Homo sapiens (human) ]

    Gene ID: 127294, updated on 27-Nov-2024

    Summary

    Official Symbol
    MYOM3provided by HGNC
    Official Full Name
    myomesin 3provided by HGNC
    Primary source
    HGNC:HGNC:26679
    See related
    Ensembl:ENSG00000142661 MIM:616832; AllianceGenome:HGNC:26679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in sarcomere organization. Predicted to be located in M band. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart (RPKM 41.6), kidney (RPKM 17.2) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MYOM3 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24056041..24112135, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23893755..23949845, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24382531..24438625, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376863 Neighboring gene ribosomal protein L36 pseudogene 5 Neighboring gene uncharacterized LOC107984931 Neighboring gene MYOM3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24404247-24404747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24408271-24408772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24419469-24420132 Neighboring gene uncharacterized LOC124903878 Neighboring gene uncharacterized LOC105376864 Neighboring gene Sharpr-MPRA regulatory region 3135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24433598-24434138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24438827-24439335 Neighboring gene Sharpr-MPRA regulatory region 13639 Neighboring gene interleukin 22 receptor subunit alpha 1 Neighboring gene uncharacterized LOC124903879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24479387-24479984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24479985-24480582 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:24480583-24481180 Neighboring gene interferon lambda receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35961, MGC71483

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in M band ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    myomesin-3
    Names
    myomesin family, member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152372.4NP_689585.3  myomesin-3

      See identical proteins and their annotated locations for NP_689585.3

      Status: VALIDATED

      Source sequence(s)
      AL591178, BX647453
      Consensus CDS
      CCDS41281.1
      UniProtKB/Swiss-Prot
      A6NF75, Q5VTT5, Q5VTT6, Q6AWC0, Q6AWC1, Q6NXF9, Q6ZRG7, Q7Z3G9, Q8NA11, Q96C54
      Related
      ENSP00000363557.3, ENST00000374434.4
      Conserved Domains (3) summary
      cd00063
      Location:802891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:13341337
      Ig; Ig strand A [structural motif]
      cl11960
      Location:13341424
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      24056041..24112135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23893755..23949845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)