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    PPP1R2B PPP1R2 family member B [ Homo sapiens (human) ]

    Gene ID: 153743, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PPP1R2Bprovided by HGNC
    Official Full Name
    PPP1R2 family member Bprovided by HGNC
    Primary source
    HGNC:HGNC:16318
    See related
    Ensembl:ENSG00000231989 AllianceGenome:HGNC:16318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPP1R2P3
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PPP1R2B in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (156850295..156852528)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (157369312..157371545)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156277306..156279539)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene sarcoglycan delta Neighboring gene uncharacterized LOC105377673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23494 Neighboring gene NANOG hESC enhancer GRCh37_chr5:156225176-156225677 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:156229076-156229967 Neighboring gene RNA, U6 small nuclear 556, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:156340819-156341764 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:156339619-156340818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23496 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:156441149-156441653 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:156441654-156442157 Neighboring gene apolipoprotein O pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:156477155-156477714 Neighboring gene T cell immunoglobulin and mucin domain containing 4 Neighboring gene hepatitis A virus cellular receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. Korrodi-Gregório L, et al. BMC Cell Biol, 2013 Mar 18. PMID 23506001, Free PMC Article
    2. Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes. Korrodi-Gregório L, et al. BMC Evol Biol, 2013 Nov 6. PMID 24195737, Free PMC Article
    3. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. Sanséau P, et al. Mamm Genome, 1994 Aug. PMID 7949733
    4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Ceulemans H, et al. Bioessays, 2002 Apr. PMID 11948623
    5. Identification of the human testis protein phosphatase 1 interactome. Fardilha M, et al. Biochem Pharmacol, 2011 Nov 15. PMID 21382349

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPP1R2P3 protein binds directly to PPP1CC and that this inhibitor cannot be phosphorylated by GSK3.
      Title: Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC87149

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase inhibitor 2 family member B
    Names
    protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 3
    protein phosphatase 1, regulatory subunit 2 pseudogene 3
    protein phosphatase inhibitor 2-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_206858.3 → NP_996740.2  protein phosphatase inhibitor 2 family member B

      Status: VALIDATED

      Source sequence(s)
      AC011414, BC066922
      Consensus CDS
      CCDS87340.1
      UniProtKB/Swiss-Prot
      G1AUC5, Q6NXS1
      UniProtKB/TrEMBL
      E7EMN6
      Related
      ENSP00000490297.1, ENST00000522232.3
      Conserved Domains (1) summary
      pfam04979
      Location:45 → 164
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      156850295..156852528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      157369312..157371545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_038443.1: Suppressed sequence

      Description
      NR_038443.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXS1.2 GenPept UniProtKB/Swiss-Prot:Q6NXS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials