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    ZNF428 zinc finger protein 428 [ Homo sapiens (human) ]

    Gene ID: 126299, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF428provided by HGNC
    Official Full Name
    zinc finger protein 428provided by HGNC
    Primary source
    HGNC:HGNC:20804
    See related
    Ensembl:ENSG00000131116 AllianceGenome:HGNC:20804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Zfp428; C19orf37
    Summary
    Predicted to enable metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 19.1), testis (RPKM 14.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF428 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43607224..43619629, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46428867..46441288, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44111376..44123781, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14728 Neighboring gene immunity related GTPase Q Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44098910-44099706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14730 Neighboring gene zinc finger protein 576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene cell adhesion molecule 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10725 Neighboring gene plasminogen activator, urokinase receptor Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma. Li XY, et al. Leukemia, 2023 Jan. PMID 36352191, Free PMC Article
    2. The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response. Cámara-Quílez M, et al. Cancers (Basel), 2020 Aug 27. PMID 32867128, Free PMC Article
    3. Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications. Barreiro-Alonso A, et al. Cancers (Basel), 2019 Nov 5. PMID 31694235, Free PMC Article
    4. Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. Montes de Oca R, et al. PLoS One, 2009 Sep 16. PMID 19759913, Free PMC Article
    5. Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer. Barreiro-Alonso A, et al. Oncotarget, 2018 Apr 10. PMID 29721183, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC51082

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 428
    Names
    enzyme-like protein PIT13

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182498.4 → NP_872304.2  zinc finger protein 428

      See identical proteins and their annotated locations for NP_872304.2

      Status: VALIDATED

      Source sequence(s)
      AC006276, BC015950, BC045799, CN355560
      Consensus CDS
      CCDS12626.1
      UniProtKB/Swiss-Prot
      O95054, Q6X3Y3, Q96B54
      UniProtKB/TrEMBL
      I6L9C8
      Related
      ENSP00000300811.2, ENST00000300811.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43607224..43619629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438168.1 → XP_047294124.1  zinc finger protein 428 isoform X1

      UniProtKB/Swiss-Prot
      O95054, Q6X3Y3, Q96B54
      UniProtKB/TrEMBL
      I6L9C8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46428867..46441288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319796.1 → XP_054175771.1  zinc finger protein 428 isoform X1

      UniProtKB/Swiss-Prot
      O95054, Q6X3Y3, Q96B54
      UniProtKB/TrEMBL
      I6L9C8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B54.2 GenPept UniProtKB/Swiss-Prot:Q96B54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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