PLPPR3 phospholipid phosphatase related 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLPPR3provided by HGNC
Official Full Name: phospholipid phosphatase related 3provided by HGNC
Primary source: HGNC:HGNC:23497
See related: Ensembl:ENSG00000129951 MIM:610391; AllianceGenome:HGNC:23497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPR3; PRG2; LPPR3; PRG-2
Summary: The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in bone marrow (RPKM 2.7), brain (RPKM 2.5) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (812488..823797, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (766962..778213, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (812488..821955, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phospholipid phosphatase-related protein type 3

Names: PAP-2-like protein 2; inactive phospholipid phosphatase PLPPR3; lipid phosphate phosphatase-related protein type 3; plasticity-related gene 2 protein

NP_001257295.1

EC 3.1.3.4

NP_079164.1

EC 3.1.3.4

XP_011526619.1

EC 3.1.3.4

XP_054178182.1

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270366.2 → NP_001257295.1 phospholipid phosphatase-related protein type 3 isoform 2

See identical proteins and their annotated locations for NP_001257295.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.

Source sequence(s)

AC004799, AL136596, AY436785, BC012339

Consensus CDS

CCDS58636.1

UniProtKB/Swiss-Prot

Q6T4P5, Q86XQ4, Q96EH1, Q9BQF9, Q9HAJ4

UniProtKB/TrEMBL

H0YBY4

Related

ENSP00000430297.1, ENST00000520876.8

Conserved Domains (1) summary

cd03384
Location:129 → 278

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_024888.3 → NP_079164.1 phospholipid phosphatase-related protein type 3 isoform 1

See identical proteins and their annotated locations for NP_079164.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)

Source sequence(s)

AC004799, AC006273, AL136596, BC012339

Consensus CDS

CCDS12043.1

UniProtKB/TrEMBL

H0YBY4

Related

ENSP00000352962.2, ENST00000359894.6

Conserved Domains (1) summary

cd03384
Location:129 → 306

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

812488..823797 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528317.4 → XP_011526619.1 phospholipid phosphatase-related protein type 3 isoform X1

See identical proteins and their annotated locations for XP_011526619.1

UniProtKB/TrEMBL

H0YBY4

Conserved Domains (1) summary

cd03384
Location:129 → 306

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...