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    RPSA2 ribosomal protein SA 2 [ Homo sapiens (human) ]

    Gene ID: 388524, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RPSA2provided by HGNC
    Official Full Name
    ribosomal protein SA 2provided by HGNC
    Primary source
    HGNC:HGNC:36809
    See related
    Ensembl:ENSG00000288920 AllianceGenome:HGNC:36809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    67LR; LamR; 37LRP; LRP/LR; LBP/p40; RPSAP58; RPSA_30_1642
    Summary
    Predicted to enable laminin binding activity and laminin receptor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cell adhesion; ribosomal small subunit assembly; and translation. Predicted to be located in several cellular components, including nucleus; plasma membrane; and ribosome. Predicted to be part of cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 296.8), lymph node (RPKM 201.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See RPSA2 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23758496..23871188)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23898911..24016747)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23941298..24053990)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:23848667-23849407 Neighboring gene zinc finger protein 675 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23868450-23869420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14394 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23906366-23907280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23941373-23941891 Neighboring gene vomeronasal 1 receptor 94 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23944886-23945526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23945527-23946168 Neighboring gene zinc finger protein 681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23951857-23952358 Neighboring gene BCL2 interacting protein 3 pseudogene 39 Neighboring gene uncharacterized LOC124904677 Neighboring gene zinc finger protein 726 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078454-24078954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:24078955-24079455 Neighboring gene zinc finger protein 726 Neighboring gene uncharacterized LOC100505851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Nguyen TV, et al. Mol Cell, 2016 Mar 17. PMID 26990986, Free PMC Article
    2. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. Li Z, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29228324, Free PMC Article
    3. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article
    4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
    5. SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage. Wang F, et al. Research (Wash D C), 2023. PMID 37223481, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables laminin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS2B
    Names
    37 kDa laminin receptor
    37/67 kDa laminin receptor
    40S ribosomal protein SA
    40S ribosomal protein SA2
    67 kDa laminin receptor
    laminin receptor 1
    laminin-binding protein precursor p40
    ribosomal protein SA pseudogene 58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355283.3 → NP_001342212.1  small ribosomal subunit protein uS2B

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804
      Consensus CDS
      CCDS92575.1
      UniProtKB/Swiss-Prot
      A0A8I5KQE6
      UniProtKB/TrEMBL
      Q96RS2
      Related
      ENSP00000509526.1, ENST00000484897.4
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 250
      PTZ00254; 40S ribosomal protein SA; Provisional

    2. NM_001355287.3 → NP_001342216.1  small ribosomal subunit protein uS2B

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804
      Consensus CDS
      CCDS92575.1
      UniProtKB/Swiss-Prot
      A0A8I5KQE6
      UniProtKB/TrEMBL
      Q96RS2
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 250
      PTZ00254; 40S ribosomal protein SA; Provisional

    3. NM_001387845.1 → NP_001374774.1  small ribosomal subunit protein uS2B

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804
      Consensus CDS
      CCDS92575.1
      UniProtKB/Swiss-Prot
      A0A8I5KQE6
      UniProtKB/TrEMBL
      Q96RS2
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 250
      PTZ00254; 40S ribosomal protein SA; Provisional

    4. NM_001387846.1 → NP_001374775.1  small ribosomal subunit protein uS2B

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804
      Consensus CDS
      CCDS92575.1
      UniProtKB/Swiss-Prot
      A0A8I5KQE6
      UniProtKB/TrEMBL
      Q96RS2
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 250
      PTZ00254; 40S ribosomal protein SA; Provisional

    RNA

    1. NR_149350.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the entire ribosomal protein SA coding region but overlaps a region that encodes zinc finger repeats.
      Source sequence(s)
      AC139769, KF495804
      Related
      ENST00000689525.1

    2. NR_149351.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks the entire ribosomal protein SA coding region but overlaps a region that encodes zinc finger repeats.
      Source sequence(s)
      AC139769, KF495804

    3. NR_149352.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks the entire ribosomal protein SA coding region but overlaps a region that encodes zinc finger repeats.
      Source sequence(s)
      AC139769, KF495804

    4. NR_170708.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804

    5. NR_170709.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804
      Related
      ENST00000475499.2

    6. NR_170710.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804

    7. NR_170711.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804

    8. NR_170712.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804
      Related
      ENST00000692590.1

    9. NR_170713.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769, KF495804

    10. NR_170714.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139769

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      23758496..23871188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      23898911..24016747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005472.1: Suppressed sequence

      Description
      NM_001005472.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A8I5KQE6.1 GenPept UniProtKB/Swiss-Prot:A0A8I5KQE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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