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    ARSG arylsulfatase G [ Homo sapiens (human) ]

    Gene ID: 22901, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARSGprovided by HGNC
    Official Full Name
    arylsulfatase Gprovided by HGNC
    Primary source
    HGNC:HGNC:24102
    See related
    Ensembl:ENSG00000141337 MIM:610008; AllianceGenome:HGNC:24102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USH4
    Summary
    The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Ubiquitous expression in thyroid (RPKM 2.8), placenta (RPKM 2.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARSG in Genome Data Viewer
    Location:
    17q24.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68259170..68452019)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (69135746..69328713)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66255311..66448160)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66196439-66197255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8895 Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66224773-66225658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66242704-66243250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66243251-66243796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8898 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66287460-66287634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12644 Neighboring gene solute carrier family 16 member 6 Neighboring gene Sharpr-MPRA regulatory region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340983-66341483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340482-66340982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66374359-66374878 Neighboring gene MPRA-validated peak2959 silencer Neighboring gene tRNA-undetermined (NNN) 5-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409262-66409920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409921-66410577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66432181-66432681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8900 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66453793-66454079 Neighboring gene microRNA 635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8902 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66494688-66494871 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66508045-66508618 Neighboring gene Sharpr-MPRA regulatory region 15560 Neighboring gene FAM20A golgi associated secretory pathway pseudokinase Neighboring gene Sharpr-MPRA regulatory region 13674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66627729-66628228 Neighboring gene long intergenic non-protein coding RNA 1482

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Usher syndrome, type 4
    MedGen: C4748364 OMIM: 618144 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus?
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-sulfoglucosamine-3-sulfatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables arylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arylsulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables arylsulfatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfur compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arylsulfatase G
    Names
    ASG
    N-sulfoglucosamine-3-sulfatase
    NP_001254656.1
    NP_001339828.1
    NP_001339829.1
    NP_001339830.1
    NP_001339831.1
    NP_001339832.1
    NP_001339833.1
    NP_001339834.1
    NP_001339835.1
    NP_001339836.1
    NP_001339838.1
    NP_001339839.1
    NP_055775.2
    XP_011522838.1
    XP_011522839.1
    XP_011522848.1
    XP_016879849.1
    XP_016879854.1
    XP_016879857.1
    XP_047291588.1
    XP_047291589.1
    XP_047291590.1
    XP_047291591.1
    XP_047291592.1
    XP_047291593.1
    XP_047291594.1
    XP_047291595.1
    XP_047291596.1
    XP_047291597.1
    XP_047291598.1
    XP_047291599.1
    XP_047291600.1
    XP_047291601.1
    XP_047291602.1
    XP_047291603.1
    XP_047291604.1
    XP_047291605.1
    XP_047291606.1
    XP_047291607.1
    XP_047291608.1
    XP_047291609.1
    XP_047291610.1
    XP_047291611.1
    XP_054171473.1
    XP_054171474.1
    XP_054171475.1
    XP_054171476.1
    XP_054171477.1
    XP_054171478.1
    XP_054171479.1
    XP_054171480.1
    XP_054171481.1
    XP_054171482.1
    XP_054171483.1
    XP_054171484.1
    XP_054171485.1
    XP_054171486.1
    XP_054171487.1
    XP_054171488.1
    XP_054171489.1
    XP_054171490.1
    XP_054171491.1
    XP_054171492.1
    XP_054171493.1
    XP_054171494.1
    XP_054171495.1
    XP_054171496.1
    XP_054171497.1
    XP_054171498.1
    XP_054171499.1
    XP_054171500.1
    XP_054171501.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032814.2 RefSeqGene

      Range
      37407..166726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267727.2NP_001254656.1  arylsulfatase G isoform 1 precursor

      See identical proteins and their annotated locations for NP_001254656.1

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780
      Consensus CDS
      CCDS11676.1
      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Related
      ENSP00000480910.1, ENST00000621439.5
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G
    2. NM_001352899.2NP_001339828.1  arylsulfatase G isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, CA308403
      Consensus CDS
      CCDS11676.1
      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G
    3. NM_001352900.2NP_001339829.1  arylsulfatase G isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, BC012375
      Consensus CDS
      CCDS11676.1
      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G
    4. NM_001352901.2NP_001339830.1  arylsulfatase G isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, BC012375
      Consensus CDS
      CCDS11676.1
      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G
    5. NM_001352902.2NP_001339831.1  arylsulfatase G isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, CA308403
      Consensus CDS
      CCDS11676.1
      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G
    6. NM_001352903.2NP_001339832.1  arylsulfatase G isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, BC012375
      Conserved Domains (1) summary
      cd16161
      Location:35468
      ARSG; arylsulfatase G
    7. NM_001352904.2NP_001339833.1  arylsulfatase G isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, CA308403
      Conserved Domains (1) summary
      cd16161
      Location:35468
      ARSG; arylsulfatase G
    8. NM_001352905.2NP_001339834.1  arylsulfatase G isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, BM664718
      Conserved Domains (1) summary
      cd16161
      Location:35468
      ARSG; arylsulfatase G
    9. NM_001352906.2NP_001339835.1  arylsulfatase G isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, CA308403
      Conserved Domains (1) summary
      cd16161
      Location:35468
      ARSG; arylsulfatase G
    10. NM_001352907.2NP_001339836.1  arylsulfatase G isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, BC012375
      Conserved Domains (1) summary
      cd16161
      Location:35468
      ARSG; arylsulfatase G
    11. NM_001352909.2NP_001339838.1  arylsulfatase G isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780, BM664718
      Conserved Domains (1) summary
      cl23718
      Location:35420
      ALP_like; alkaline phosphatases and sulfatases
    12. NM_001352910.2NP_001339839.1  arylsulfatase G isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005332, AC007780
      Conserved Domains (1) summary
      cd16161
      Location:35436
      ARSG; arylsulfatase G
    13. NM_014960.5NP_055775.2  arylsulfatase G isoform 1 precursor

      See identical proteins and their annotated locations for NP_055775.2

      Status: REVIEWED

      Source sequence(s)
      AB023218, AC005332, AC007780, AY358380, BC012375
      Consensus CDS
      CCDS11676.1
      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Related
      ENSP00000407193.2, ENST00000448504.6
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      68259170..68452019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435644.1XP_047291600.1  arylsulfatase G isoform X7

    2. XM_047435647.1XP_047291603.1  arylsulfatase G isoform X6

    3. XM_047435645.1XP_047291601.1  arylsulfatase G isoform X7

    4. XM_047435639.1XP_047291595.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
    5. XM_047435632.1XP_047291588.1  arylsulfatase G isoform X1

    6. XM_047435649.1XP_047291605.1  arylsulfatase G isoform X8

    7. XM_047435653.1XP_047291609.1  arylsulfatase G isoform X10

    8. XM_047435655.1XP_047291611.1  arylsulfatase G isoform X11

    9. XM_047435643.1XP_047291599.1  arylsulfatase G isoform X6

    10. XM_047435634.1XP_047291590.1  arylsulfatase G isoform X1

    11. XM_047435637.1XP_047291593.1  arylsulfatase G isoform X3

    12. XM_047435642.1XP_047291598.1  arylsulfatase G isoform X6

    13. XM_047435633.1XP_047291589.1  arylsulfatase G isoform X1

    14. XM_011524537.2XP_011522839.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_011522839.1

      Conserved Domains (2) summary
      COG3119
      Location:35457
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16161
      Location:35496
      ARSG; arylsulfatase G
    15. XM_011524536.3XP_011522838.1  arylsulfatase G isoform X1

      See identical proteins and their annotated locations for XP_011522838.1

      Conserved Domains (2) summary
      COG3119
      Location:35457
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16161
      Location:35496
      ARSG; arylsulfatase G
    16. XM_017024368.2XP_016879857.1  arylsulfatase G isoform X8

      Conserved Domains (2) summary
      COG3119
      Location:35354
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cl23718
      Location:35363
      ALP_like; alkaline phosphatases and sulfatases
    17. XM_047435636.1XP_047291592.1  arylsulfatase G isoform X2

    18. XM_047435641.1XP_047291597.1  arylsulfatase G isoform X5

    19. XM_047435651.1XP_047291607.1  arylsulfatase G isoform X10

    20. XM_047435652.1XP_047291608.1  arylsulfatase G isoform X11

    21. XM_047435640.1XP_047291596.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
    22. XM_017024360.3XP_016879849.1  arylsulfatase G isoform X1

      Conserved Domains (2) summary
      COG3119
      Location:35457
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16161
      Location:35496
      ARSG; arylsulfatase G
    23. XM_047435648.1XP_047291604.1  arylsulfatase G isoform X8

    24. XM_047435654.1XP_047291610.1  arylsulfatase G isoform X10

    25. XM_047435646.1XP_047291602.1  arylsulfatase G isoform X7

    26. XM_047435635.1XP_047291591.1  arylsulfatase G isoform X1

    27. XM_017024365.2XP_016879854.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
      Conserved Domains (1) summary
      cd16161
      Location:35469
      ARSG; arylsulfatase G
    28. XM_047435638.1XP_047291594.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
    29. XM_047435650.1XP_047291606.1  arylsulfatase G isoform X9

      UniProtKB/TrEMBL
      B4DQ74, J9JIG6
      Related
      ENSP00000413953.2, ENST00000452479.6
    30. XM_011524546.3XP_011522848.1  arylsulfatase G isoform X12

      Conserved Domains (1) summary
      cl23718
      Location:1247
      ALP_like; alkaline phosphatases and sulfatases

    RNA

    1. XR_007065287.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      69135746..69328713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315513.1XP_054171488.1  arylsulfatase G isoform X7

    2. XM_054315517.1XP_054171492.1  arylsulfatase G isoform X6

    3. XM_054315514.1XP_054171489.1  arylsulfatase G isoform X7

    4. XM_054315507.1XP_054171482.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
    5. XM_054315499.1XP_054171474.1  arylsulfatase G isoform X1

    6. XM_054315518.1XP_054171493.1  arylsulfatase G isoform X8

    7. XM_054315524.1XP_054171499.1  arylsulfatase G isoform X10

    8. XM_054315526.1XP_054171501.1  arylsulfatase G isoform X11

    9. XM_054315512.1XP_054171487.1  arylsulfatase G isoform X6

    10. XM_054315503.1XP_054171478.1  arylsulfatase G isoform X1

    11. XM_054315506.1XP_054171481.1  arylsulfatase G isoform X3

    12. XM_054315511.1XP_054171486.1  arylsulfatase G isoform X6

    13. XM_054315502.1XP_054171477.1  arylsulfatase G isoform X1

    14. XM_054315501.1XP_054171476.1  arylsulfatase G isoform X1

    15. XM_054315498.1XP_054171473.1  arylsulfatase G isoform X1

    16. XM_054315516.1XP_054171491.1  arylsulfatase G isoform X8

    17. XM_054315505.1XP_054171480.1  arylsulfatase G isoform X2

    18. XM_054315510.1XP_054171485.1  arylsulfatase G isoform X5

    19. XM_054315521.1XP_054171496.1  arylsulfatase G isoform X10

    20. XM_054315522.1XP_054171497.1  arylsulfatase G isoform X11

    21. XM_054315509.1XP_054171484.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
    22. XM_054315500.1XP_054171475.1  arylsulfatase G isoform X1

    23. XM_054315519.1XP_054171494.1  arylsulfatase G isoform X8

    24. XM_054315525.1XP_054171500.1  arylsulfatase G isoform X10

    25. XM_054315515.1XP_054171490.1  arylsulfatase G isoform X7

    26. XM_054315504.1XP_054171479.1  arylsulfatase G isoform X1

    27. XM_054315508.1XP_054171483.1  arylsulfatase G isoform X4

      UniProtKB/Swiss-Prot
      Q6UXF2, Q96EG1, Q9Y2K4
    28. XM_054315520.1XP_054171495.1  arylsulfatase G isoform X9

      UniProtKB/TrEMBL
      B4DQ74, J9JIG6
    29. XM_054315523.1XP_054171498.1  arylsulfatase G isoform X12

    RNA

    1. XR_008484799.1 RNA Sequence