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    TAS2R20 taste 2 receptor member 20 [ Homo sapiens (human) ]

    Gene ID: 259295, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAS2R20provided by HGNC
    Official Full Name
    taste 2 receptor member 20provided by HGNC
    Primary source
    HGNC:HGNC:19109
    See related
    Ensembl:ENSG00000255837 MIM:613962; AllianceGenome:HGNC:19109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R20; T2R49; T2R56; TAS2R49
    Summary
    This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]
    Orthologs
    all
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    Genomic context

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    See TAS2R20 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10995961..10998304, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10868982..10871325, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11148560..11150903, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:11127502-11128380 Neighboring gene taste 2 receptor member 15 pseudogene Neighboring gene taste 2 receptor member 50 Neighboring gene taste 2 receptor member 19 Neighboring gene taste 2 receptor member 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Frequent expansions of the bitter taste receptor gene repertoire during evolution of mammals in the Euarchontoglires clade. Hayakawa T, et al. Mol Biol Evol, 2014 Aug. PMID 24758778
    2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Conte C, et al. Cytogenet Genome Res, 2002. PMID 12584440
    3. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe B, et al. Nat Genet, 2002 Nov. PMID 12379855
    4. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
    5. Receptors for bitter and sweet taste. Montmayeur JP, et al. Curr Opin Neurobiol, 2002 Aug. PMID 12139982

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119118, MGC119119, MGC119120, MGC119121, MGC134637

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bitter taste receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 20
    Names
    taste receptor type 2 member 56
    taste receptor, type 2, member 49

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051254.1 RefSeqGene

      Range
      5001..7344
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176889.4 → NP_795370.2  taste receptor type 2 member 20

      See identical proteins and their annotated locations for NP_795370.2

      Status: REVIEWED

      Source sequence(s)
      AC018630, BC100916, C20782, CD722569
      Consensus CDS
      CCDS8639.1
      UniProtKB/Swiss-Prot
      P59543, P59549, Q2HIZ4, Q496D8, Q645X9
      UniProtKB/TrEMBL
      A0A0J9YXF7
      Related
      ENSP00000441624.1, ENST00000538986.2
      Conserved Domains (1) summary
      cd15027
      Location:3 → 294
      7tm_TAS2R43-like; mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10995961..10998304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      194667..197010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      194656..196999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10868982..10871325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59543.2 GenPept UniProtKB/Swiss-Prot:P59543

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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