KAT7 lysine acetyltransferase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KAT7provided by HGNC
Official Full Name: lysine acetyltransferase 7provided by HGNC
Primary source: HGNC:HGNC:17016
See related: Ensembl:ENSG00000136504 MIM:609880; AllianceGenome:HGNC:17016
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HBO1; HBOA; MYST2; ZC2HC7
Summary: The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
Expression: Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (49788681..49835026)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (50651771..50698127)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (47866043..47912388)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Title: Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.
Title: Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.
KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
Title: KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
HBO1 determines SMAD action in pluripotency and mesendoderm specification.
Title: HBO1 determines SMAD action in pluripotency and mesendoderm specification.
Histone acetylation by HBO1 (KAT7) activates Wnt/beta-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Title: Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
Title: The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer.
Title: KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer.
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Title: KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
KAT7 promoted gastric cancer progression through promoting YAP1 activation.
Title: KAT7 promoted gastric cancer progression through promoting YAP1 activation.
HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth.
Title: HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
integrase	gag-pol	Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS7479 (e-PCR)
- UniSTS:47396

WI-14886 (e-PCR)
- UniSTS:15399

RH11199 (e-PCR)
- UniSTS:58410

GDB:451733 (e-PCR)
- UniSTS:99533

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA replication origin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K12 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables histone H4K16 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K5 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K8 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication-dependent chromatin disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in internal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in natural killer cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription, elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated DNA replication initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of nucleotide-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to actinomycin D	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anisomycin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to dithiothreitol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydroxyurea	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sorbitol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated protein kinase signaling cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
part_of histone H3-K14 acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone H3-K14 acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone acetyltransferase KAT7

Names: K(lysine) acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; histone acetyltransferase MYST2; histone acetyltransferase binding to ORC1

NP_001186084.1

EC 2.3.1.48

NP_001186085.1

EC 2.3.1.48

NP_001186086.1

EC 2.3.1.48

NP_001186087.1

EC 2.3.1.48

NP_001333635.1

EC 2.3.1.48

NP_008998.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051976.2 RefSeqGene

Range

5002..51347

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001199155.2 → NP_001186084.1 histone acetyltransferase KAT7 isoform 2

See identical proteins and their annotated locations for NP_001186084.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC015795, AC027801

Consensus CDS

CCDS56035.1

UniProtKB/TrEMBL

A0A9L9PXJ9

Related

ENSP00000516419.1, ENST00000706506.1

Conserved Domains (3) summary

PLN00104
Location:294 → 579

PLN00104; MYST -like histone acetyltransferase; Provisional

cd16378
Location:209 → 262

CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins

pfam01530
Location:184 → 212

zf-C2HC; Zinc finger, C2HC type
NM_001199156.2 → NP_001186085.1 histone acetyltransferase KAT7 isoform 3

See identical proteins and their annotated locations for NP_001186085.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC015795, AC027801

Consensus CDS

CCDS56037.1

UniProtKB/TrEMBL

B3KVJ2

Related

ENSP00000413415.2, ENST00000454930.6

Conserved Domains (2) summary

PLN00104
Location:185 → 470

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam01530
Location:53 → 73

zf-C2HC; Zinc finger, C2HC type
NM_001199157.2 → NP_001186086.1 histone acetyltransferase KAT7 isoform 4

See identical proteins and their annotated locations for NP_001186086.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC015795, AC027801

Consensus CDS

CCDS56036.1

UniProtKB/TrEMBL

A0A9L9PX81

Related

ENSP00000424577.1, ENST00000509773.5

Conserved Domains (3) summary

PLN00104
Location:214 → 499

PLN00104; MYST -like histone acetyltransferase; Provisional

cd16378
Location:129 → 182

CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins

pfam01530
Location:113 → 132

zf-C2HC; Zinc finger, C2HC type
NM_001199158.2 → NP_001186087.1 histone acetyltransferase KAT7 isoform 5

See identical proteins and their annotated locations for NP_001186087.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC015795, AC027801

Consensus CDS

CCDS56038.1

UniProtKB/TrEMBL

A0A9L9PX81

Related

ENSP00000423385.1, ENST00000510819.5

Conserved Domains (3) summary

PLN00104
Location:155 → 440

PLN00104; MYST -like histone acetyltransferase; Provisional

cd16378
Location:70 → 123

CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins

pfam01530
Location:53 → 73

zf-C2HC; Zinc finger, C2HC type
NM_001346706.2 → NP_001333635.1 histone acetyltransferase KAT7 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC015795, AC027801

UniProtKB/TrEMBL

A0A9L9PX81, A0A9L9PXR9

Related

ENSP00000516479.1, ENST00000706640.1

Conserved Domains (2) summary

PLN00104
Location:244 → 529

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam01530
Location:113 → 132

zf-C2HC; Zinc finger, C2HC type
NM_007067.5 → NP_008998.1 histone acetyltransferase KAT7 isoform 1

See identical proteins and their annotated locations for NP_008998.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC015795, AC027801

Consensus CDS

CCDS11554.1

UniProtKB/Swiss-Prot

B3KN74, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15, G5E9K7, O95251

UniProtKB/TrEMBL

A0AA34QVH8

Related

ENSP00000259021.4, ENST00000259021.9

Conserved Domains (2) summary

PLN00104
Location:324 → 609

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam01530
Location:184 → 212

zf-C2HC; Zinc finger, C2HC type