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    Atg7 autophagy related 7 [ Mus musculus (house mouse) ]

    Gene ID: 74244, updated on 28-Jan-2025

    Summary

    Official Symbol
    Atg7provided by MGI
    Official Full Name
    autophagy related 7provided by MGI
    Primary source
    MGI:MGI:1921494
    See related
    Ensembl:ENSMUSG00000030314 AllianceGenome:MGI:1921494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agp7; Apg7l; Atg7l; Gm21553; 1810013K23Rik
    Summary
    This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 13.1), testis adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atg7 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114620075..114837565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114643127..114860604)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38875 Neighboring gene histamine receptor H1 Neighboring gene STARR-positive B cell enhancer ABC_E9098 Neighboring gene STARR-seq mESC enhancer starr_17063 Neighboring gene STARR-seq mESC enhancer starr_17064 Neighboring gene predicted gene, 52917 Neighboring gene STARR-positive B cell enhancer ABC_E11331 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114824988-114825171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114825181-114825290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114843851-114843960 Neighboring gene STARR-seq mESC enhancer starr_17069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114870691-114870844 Neighboring gene STARR-positive B cell enhancer ABC_E4855 Neighboring gene STARR-positive B cell enhancer mm9_chr6:114872780-114873081 Neighboring gene vestigial like family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E4856 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene predicted gene, 38876 Neighboring gene predicted gene, 52944

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Atg12 activating enzyme activity  
    enables Atg12 activating enzyme activity PubMed 
    enables Atg12 activating enzyme activity PubMed 
    enables Atg12 activating enzyme activity  
    enables Atg8 activating enzyme activity  
    enables Atg8 activating enzyme activity PubMed 
    enables protein binding PubMed 
    enables protein homodimerization activity  
    Items 1 - 25 of 84
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior PubMed 
    acts_upstream_of apoptotic process PubMed 
    involved_in autophagosome assembly  
    acts_upstream_of_or_within autophagosome assembly PubMed 
    involved_in autophagosome assembly PubMed 
    involved_in autophagosome assembly  
    acts_upstream_of_or_within autophagy PubMed 
    involved_in autophagy PubMed 
    acts_upstream_of_or_within autophagy PubMed 
    involved_in autophagy  
    involved_in autophagy  
    acts_upstream_of_or_within autophagy of mitochondrion PubMed 
    acts_upstream_of cardiac muscle cell apoptotic process PubMed 
    acts_upstream_of_or_within cardiac muscle cell development PubMed 
    involved_in cellular response to hyperoxia  
    involved_in cellular response to hyperoxia  
    involved_in cellular response to nitrogen starvation  
    acts_upstream_of_or_within cellular response to reactive oxygen species PubMed 
    involved_in cellular response to sodium arsenite  
    acts_upstream_of_or_within cellular response to starvation PubMed 
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    acts_upstream_of_or_within central nervous system neuron axonogenesis PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell layer development PubMed 
    acts_upstream_of_or_within cerebral cortex development PubMed 
    involved_in chaperone-mediated autophagy  
    acts_upstream_of_positive_effect chromatin organization PubMed 
    acts_upstream_of_or_within defense response to virus PubMed 
    involved_in defense response to virus  
    acts_upstream_of establishment of localization in cell PubMed 
    acts_upstream_of_or_within innate immune response PubMed 
    acts_upstream_of insulin secretion involved in cellular response to glucose stimulus PubMed 
    acts_upstream_of_or_within intracellular amino acid homeostasis PubMed 
    acts_upstream_of_or_within intracellular sphingolipid homeostasis PubMed 
    acts_upstream_of_or_within liver development PubMed 
    acts_upstream_of_or_within macroautophagy PubMed 
    involved_in macroautophagy  
    acts_upstream_of_or_within membrane organization PubMed 
    acts_upstream_of_or_within mitochondrion organization PubMed 
    involved_in mitophagy  
    involved_in mitophagy PubMed 
    involved_in mitophagy  
    acts_upstream_of mucus secretion PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process PubMed 
    involved_in negative regulation of mitochondrial DNA replication  
    involved_in negative regulation of neuron apoptotic process  
    acts_upstream_of_or_within negative regulation of phagocytosis PubMed 
    acts_upstream_of_or_within negative regulation of sphingolipid biosynthetic process PubMed 
    acts_upstream_of_or_within negative regulation of type B pancreatic cell apoptotic process PubMed 
    acts_upstream_of_or_within negative stranded viral RNA replication PubMed 
    acts_upstream_of_or_within nervous system process PubMed 
    acts_upstream_of_or_within neuron projection development PubMed 
    acts_upstream_of_or_within organelle organization PubMed 
    involved_in piecemeal microautophagy of the nucleus  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of autophagy  
    acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    acts_upstream_of_or_within positive regulation of mucus secretion PubMed 
    involved_in positive regulation of programmed cell death  
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    acts_upstream_of_or_within positive regulation of protein modification process PubMed 
    acts_upstream_of_or_within positive regulation of protein modification process PubMed 
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within protein catabolic process PubMed 
    acts_upstream_of_or_within protein lipidation PubMed 
    involved_in protein modification by small protein conjugation  
    acts_upstream_of_or_within protein modification by small protein conjugation PubMed 
    acts_upstream_of_or_within pyramidal neuron development PubMed 
    involved_in regulation of cell development PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of hemopoiesis PubMed 
    acts_upstream_of_or_within regulation of protein ubiquitination PubMed 
    acts_upstream_of_or_within response to starvation PubMed 
    involved_in rhythmic process  
    acts_upstream_of sphingolipid biosynthetic process PubMed 
    involved_in synaptic vesicle cycle PubMed 
    involved_in synaptic vesicle cycle PubMed 
    acts_upstream_of type B pancreatic cell apoptotic process PubMed 
    Items 1 - 25 of 84
    Component Evidence Code Pubs
    located_in axon  
    located_in axoneme PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in dopaminergic synapse PubMed 
    is_active_in dopaminergic synapse PubMed 
    located_in membrane  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in phagophore assembly site  
    located_in phagophore assembly site  
    is_active_in phagophore assembly site  
    located_in presynapse  

    General protein information

    Preferred Names
    ubiquitin-like modifier-activating enzyme ATG7
    Names
    ATG12-activating enzyme E1 ATG7
    autophagy-related protein 7
    ubiquitin-activating enzyme E1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253717.2NP_001240646.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 1

      See identical proteins and their annotated locations for NP_001240646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122843, AC149276, AC170088
      Consensus CDS
      CCDS59697.1
      UniProtKB/TrEMBL
      A0A0A0MQN4, Q3TAB9, Q3TM87
      Related
      ENSMUSP00000133215.4, ENSMUST00000169310.10
      Conserved Domains (3) summary
      cd01486
      Location:396720
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:54740
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:52359
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. NM_001253718.2NP_001240647.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 2

      See identical proteins and their annotated locations for NP_001240647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 5' coding region, resulting in initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122843, AC149276, AC170088
      Consensus CDS
      CCDS39598.1
      UniProtKB/Swiss-Prot
      Q3TCD9, Q8K4Q5, Q9D906
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Related
      ENSMUSP00000138137.2, ENSMUST00000182793.8
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    3. NM_001379130.1NP_001366059.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122843, AC149276, AC170088
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Conserved Domains (1) summary
      TIGR01381
      Location:27713
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    4. NM_028835.5NP_083111.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 2

      See identical proteins and their annotated locations for NP_083111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, resulting in the initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122843, AC149276, AC170088
      Consensus CDS
      CCDS39598.1
      UniProtKB/Swiss-Prot
      Q3TCD9, Q8K4Q5, Q9D906
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Related
      ENSMUSP00000032457.10, ENSMUST00000032457.17
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p

    RNA

    1. NR_166516.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122843, AC149276, AC170088

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      114620075..114837565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152367.1XP_036008260.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/Swiss-Prot
      Q3TCD9, Q8K4Q5, Q9D906
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    2. XM_036152368.1XP_036008261.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/Swiss-Prot
      Q3TCD9, Q8K4Q5, Q9D906
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Related
      ENSMUSP00000138779.2, ENSMUST00000182428.8
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    3. XM_036152370.1XP_036008263.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/Swiss-Prot
      Q3TCD9, Q8K4Q5, Q9D906
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    4. XM_036152369.1XP_036008262.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      UniProtKB/Swiss-Prot
      Q3TCD9, Q8K4Q5, Q9D906
      UniProtKB/TrEMBL
      Q3TAB9, Q3TM87
      Related
      ENSMUSP00000138651.2, ENSMUST00000182902.8
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
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