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    ICOSLG inducible T cell costimulator ligand [ Homo sapiens (human) ]

    Gene ID: 23308, updated on 3-Dec-2024

    Summary

    Official Symbol
    ICOSLGprovided by HGNC
    Official Full Name
    inducible T cell costimulator ligandprovided by HGNC
    Primary source
    HGNC:HGNC:17087
    See related
    Ensembl:ENSG00000160223 MIM:605717; AllianceGenome:HGNC:17087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L; IMD119
    Summary
    Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ICOSLG in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44216981..44240943, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42571002..42595008, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45642874..45660826, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45595498-45596144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45596145-45596790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45600775-45601276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45601277-45601776 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG regulatory elements GRCh37_chr21:45616066-45616566 to GRCh37_chr21:45616069-45616569 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45616946-45617124 Neighboring gene uncharacterized LOC105372832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45621734-45622497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45622498-45623260 Neighboring gene uncharacterized LOC102725065 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:45626388-45627587 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG regulatory elements GRCh37_chr21:45627759-45628259 and GRCh37_chr21:45627787-45628287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45628433-45629348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45633361-45633860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45642723-45643224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45643225-45643724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45645682-45646182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45646183-45646683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45659303-45660081 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG and IFNGR2 regulatory element GRCh37_chr21:45660637-45661636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45662586-45663124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45667417-45668358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45669258-45669773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45669774-45670290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45670291-45670805 Neighboring gene DNMT3L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45676001-45676989 Neighboring gene DNA methyltransferase 3 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:45677884-45678384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45681495-45682054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45685919-45686548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45686549-45687178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45691192-45691798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18564 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:45702827-45703430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45703431-45704032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45704033-45704636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45704637-45705238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18567 Neighboring gene autoimmune regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0653

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T follicular helper cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hyperosmotic response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ICOS ligand
    Names
    B7 homolog 2
    B7 homologue 2
    B7-like protein Gl50
    B7-related protein 1
    transmembrane protein B7-H2 ICOS ligand

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283050.2NP_001269979.1  ICOS ligand isoform b precursor

      See identical proteins and their annotated locations for NP_001269979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.
      Source sequence(s)
      AA781960, AF199028, DC365972
      Consensus CDS
      CCDS63379.1
      UniProtKB/TrEMBL
      A0A8V8TQ42
      Related
      ENSP00000339477.4, ENST00000344330.9
      Conserved Domains (2) summary
      pfam07686
      Location:20131
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:153225
      Ig; Immunoglobulin domain
    2. NM_001283051.2NP_001269980.1  ICOS ligand isoform c precursor

      See identical proteins and their annotated locations for NP_001269980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AK090492, AP001058, BQ005303
      Consensus CDS
      CCDS63377.1
      UniProtKB/Swiss-Prot
      O75144
      Related
      ENSP00000383228.3, ENST00000400377.4
      Conserved Domains (1) summary
      cl11960
      Location:36108
      Ig; Immunoglobulin domain
    3. NM_001283052.2NP_001269981.1  ICOS ligand isoform d

      See identical proteins and their annotated locations for NP_001269981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, resulting in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK294031, AP001058, BQ005303
      Consensus CDS
      CCDS93102.1
      UniProtKB/TrEMBL
      B7Z1W8, B7ZA28, B7ZA61
      Related
      ENSP00000514960.1, ENST00000700358.1
      Conserved Domains (1) summary
      cl11960
      Location:68140
      Ig; Immunoglobulin domain
    4. NM_001365759.2NP_001352688.1  ICOS ligand isoform e

      Status: VALIDATED

      Source sequence(s)
      AP001058, AP001059
      UniProtKB/TrEMBL
      A0A8V8TQ42
      Conserved Domains (1) summary
      cl11960
      Location:2104
      Ig; Immunoglobulin domain
    5. NM_001395918.1NP_001382847.1  ICOS ligand isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AP001058, AP001059
      Consensus CDS
      CCDS93104.1
      UniProtKB/TrEMBL
      A0A8V8TQ42, A0A8V8TQV9
      Related
      ENSP00000514957.1, ENST00000700355.1
      Conserved Domains (3) summary
      cd00096
      Location:154162
      Ig; Ig strand B [structural motif]
      cd20935
      Location:23135
      IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
      cl11960
      Location:149224
      Ig; Immunoglobulin domain
    6. NM_015259.6NP_056074.1  ICOS ligand isoform a precursor

      See identical proteins and their annotated locations for NP_056074.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AK314369, AP001058, BQ005303
      Consensus CDS
      CCDS42952.1
      UniProtKB/Swiss-Prot
      A8MUZ1, O75144, Q9HD18, Q9NRQ1
      UniProtKB/TrEMBL
      A0A8V8TQ42, A0N0L8
      Related
      ENSP00000384432.3, ENST00000407780.8
      Conserved Domains (2) summary
      pfam07686
      Location:20131
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:153212
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      44216981..44240943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529516.4XP_011527818.1  ICOS ligand isoform X3

      See identical proteins and their annotated locations for XP_011527818.1

      Conserved Domains (1) summary
      cl11960
      Location:2104
      Ig; Immunoglobulin domain
    2. XM_011529514.4XP_011527816.1  ICOS ligand isoform X1

      See identical proteins and their annotated locations for XP_011527816.1

      UniProtKB/TrEMBL
      A0A2R8Y5W7
      Related
      ENSP00000494882.2, ENST00000643466.2
      Conserved Domains (2) summary
      pfam07686
      Location:20131
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:153225
      Ig; Immunoglobulin domain
    3. XM_047440729.1XP_047296685.1  ICOS ligand isoform X2

    4. XM_047440730.1XP_047296686.1  ICOS ligand isoform X3

    5. XM_047440732.1XP_047296688.1  ICOS ligand isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ42
    6. XM_047440731.1XP_047296687.1  ICOS ligand isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      42571002..42595008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324408.1XP_054180383.1  ICOS ligand isoform X3

    2. XM_054324405.1XP_054180380.1  ICOS ligand isoform X1

    3. XM_054324406.1XP_054180381.1  ICOS ligand isoform X2

    4. XM_054324407.1XP_054180382.1  ICOS ligand isoform X3

    5. XM_054324411.1XP_054180386.1  ICOS ligand isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ42
    6. XM_054324412.1XP_054180387.1  ICOS ligand isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ42
    7. XM_054324410.1XP_054180385.1  ICOS ligand isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQ42
    8. XM_054324409.1XP_054180384.1  ICOS ligand isoform X4