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    NLK nemo like kinase [ Homo sapiens (human) ]

    Gene ID: 51701, updated on 10-Dec-2024

    Summary

    Official Symbol
    NLKprovided by HGNC
    Official Full Name
    nemo like kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:29858
    See related
    Ensembl:ENSG00000087095 MIM:609476; AllianceGenome:HGNC:29858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of TORC1 signaling; protein stabilization; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 18.0), adrenal (RPKM 18.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NLK in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28042677..28206074)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28984080..29146552)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26369703..26523407)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:26360641-26361840 Neighboring gene uncharacterized LOC105371709 Neighboring gene Sharpr-MPRA regulatory region 3957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8333 Neighboring gene uncharacterized LOC102724517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11918 Neighboring gene NANOG hESC enhancer GRCh37_chr17:26440640-26441141 Neighboring gene ribosomal protein S29 pseudogene 22 Neighboring gene uncharacterized LOC105371711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11919 Neighboring gene uncharacterized LOC105371710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26553198-26553848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26554499-26555148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26555149-26555798 Neighboring gene Sharpr-MPRA regulatory region 13006 Neighboring gene uncharacterized LOC105371712 Neighboring gene peptide YY 2 (pseudogene) Neighboring gene pancreatic polypeptide 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein nemo-like kinase (NLK) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ21033, DKFZp761G1211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables DNA-binding transcription factor binding PubMed 
    enables JUN kinase activity  
    enables MAP kinase activity  
    enables SH2 domain binding  
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ubiquitin protein ligase binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    serine/threonine-protein kinase NLK
    NP_057315.3
    XP_005258045.1
    XP_054172389.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016231.5 → NP_057315.3  serine/threonine-protein kinase NLK

      See identical proteins and their annotated locations for NP_057315.3

      Status: VALIDATED

      Source sequence(s)
      AC090287, AK024686, AL036279, BM723604, BQ636970, DA224552, DA573077, U69562
      Consensus CDS
      CCDS11224.2
      UniProtKB/Swiss-Prot
      B2RCX1, Q2PNI9, Q6P2A3, Q9UBE8
      UniProtKB/TrEMBL
      H0YD75
      Related
      ENSP00000384625.3, ENST00000407008.8
      Conserved Domains (1) summary
      cd07853
      Location:137 → 508
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28042677..28206074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257988.3 → XP_005258045.1  serine/threonine-protein kinase NLK isoform X1

      See identical proteins and their annotated locations for XP_005258045.1

      UniProtKB/TrEMBL
      H0YD75
      Conserved Domains (1) summary
      cd07853
      Location:137 → 479
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    RNA

    1. XR_934482.2 RNA Sequence

    2. XR_001752526.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      28984080..29146552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316414.1 → XP_054172389.1  serine/threonine-protein kinase NLK isoform X1

      UniProtKB/TrEMBL
      H0YD75

    RNA

    1. XR_008484832.1 RNA Sequence

    2. XR_008484833.1 RNA Sequence

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