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    ZNF106 zinc finger protein 106 [ Homo sapiens (human) ]

    Gene ID: 64397, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF106provided by HGNC
    Official Full Name
    zinc finger protein 106provided by HGNC
    Primary source
    HGNC:HGNC:12886
    See related
    Ensembl:ENSG00000103994 MIM:603988; AllianceGenome:HGNC:12886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SH3BP3; ZFP106; ZNF474
    Summary
    Enables RNA binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in cytosol and membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart (RPKM 62.5), fat (RPKM 20.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF106 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42412823..42491141, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40218871..40297183, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42705021..42783339, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosidase alpha, neutral C Neighboring gene BCL2 interacting protein 3 pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:42652107-42652607 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:42655654-42656620 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42676684-42677239 Neighboring gene uncharacterized LOC105370794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:42677734-42678933 Neighboring gene calpain 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9300 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42749529-42750361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42750362-42751193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9303 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42787505-42788048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42788049-42788592 Neighboring gene synaptosome associated protein 23 Neighboring gene MPRA-validated peak2311 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9304 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis. van den Berg FF, et al. Ann Surg, 2022 Jun 1. PMID 33427755
    2. Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1. Grasberger H, et al. Gene, 2005 Jan 3. PMID 15656981
    3. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany O, et al. Am J Hum Genet, 2002 Dec. PMID 12434312, Free PMC Article
    4. Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP. Contreras-Martos S, et al. Sci Rep, 2017 Jul 5. PMID 28680062, Free PMC Article
    5. An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry. Hecht M, et al. G3 (Bethesda), 2019 Jun 5. PMID 30975701, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis.
      Title: Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis.
    2. Study identified ZFP106 as a novel substrate for CBP-mediated acetylation, and showed that the fully disordered isolated ID3 in CREBBP transiently interacts with an IDR of ZFP106 in a fashion that both IDR regions are maintained.
      Title: Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34610, FLJ45841, DKFZp451A239, DKFZp686N20157

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 106
    Names
    SH3-domain binding protein 3
    zinc finger protein 474

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284306.2 → NP_001271235.1  zinc finger protein 106 isoform 2

      See identical proteins and their annotated locations for NP_001271235.1

      Status: REVIEWED

      Source sequence(s)
      AC012651
      Consensus CDS
      CCDS61602.1
      UniProtKB/TrEMBL
      A0A0C4DGM5
      Related
      ENSP00000457637.1, ENST00000565611.5
      Conserved Domains (3) summary
      COG2319
      Location:565 → 993
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:710 → 987
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:760 → 799
      7WD40; WD40 repeat [structural motif]

    2. NM_001284307.4 → NP_001271236.1  zinc finger protein 106 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      Consensus CDS
      CCDS61603.1
      UniProtKB/Swiss-Prot
      Q9H2Y7
      Related
      ENSP00000455674.1, ENST00000565380.5
      Conserved Domains (3) summary
      COG2319
      Location:608 → 1036
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:753 → 1030
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:803 → 842
      7WD40; WD40 repeat [structural motif]

    3. NM_001366844.3 → NP_001353773.1  zinc finger protein 106 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      UniProtKB/TrEMBL
      H3BS99
      Related
      ENSP00000456604.1, ENST00000565500.5
      Conserved Domains (3) summary
      cd00200
      Location:666 → 943
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:716 → 755
      7WD40; WD40 repeat [structural motif]
      pfam09184
      Location:539 → 669
      PPP4R2; PPP4R2

    4. NM_001366845.3 → NP_001353774.1  zinc finger protein 106 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      Consensus CDS
      CCDS91986.1
      UniProtKB/TrEMBL
      H3BSS6
      Related
      ENSP00000456845.2, ENST00000564754.7
      Conserved Domains (3) summary
      cd00200
      Location:1548 → 1825
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00020
      Location:7 → 29
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00039
      Location:1598 → 1637
      7WD40; WD40 repeat [structural motif]

    5. NM_001366846.3 → NP_001353775.1  zinc finger protein 106 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      Conserved Domains (3) summary
      cd00200
      Location:1461 → 1738
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00020
      Location:7 → 29
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00039
      Location:1511 → 1550
      7WD40; WD40 repeat [structural motif]

    6. NM_001381993.1 → NP_001368922.1  zinc finger protein 106 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      Conserved Domains (2) summary
      cd00200
      Location:1481 → 1758
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1531 → 1570
      7WD40; WD40 repeat [structural motif]

    7. NM_001381994.1 → NP_001368923.1  zinc finger protein 106 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      Conserved Domains (3) summary
      cd00200
      Location:820 → 1097
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00020
      Location:7 → 29
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00039
      Location:870 → 909
      7WD40; WD40 repeat [structural motif]

    8. NM_001381995.1 → NP_001368924.1  zinc finger protein 106 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      Conserved Domains (2) summary
      cd00200
      Location:759 → 1036
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:809 → 848
      7WD40; WD40 repeat [structural motif]

    9. NM_001381996.1 → NP_001368925.1  zinc finger protein 106 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      UniProtKB/TrEMBL
      H3BS99
      Conserved Domains (2) summary
      sd00039
      Location:657 → 691
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:648 → 879
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. NM_001381997.1 → NP_001368926.1  zinc finger protein 106 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      UniProtKB/TrEMBL
      H3BS99
      Conserved Domains (2) summary
      cd00200
      Location:594 → 871
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:644 → 683
      7WD40; WD40 repeat [structural motif]

    11. NM_001381998.1 → NP_001368927.1  zinc finger protein 106 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC012651, AC018362
      UniProtKB/TrEMBL
      H3BS99
      Conserved Domains (2) summary
      cd00200
      Location:666 → 943
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:716 → 755
      7WD40; WD40 repeat [structural motif]

    12. NM_022473.3 → NP_071918.1  zinc finger protein 106 isoform 1

      See identical proteins and their annotated locations for NP_071918.1

      Status: REVIEWED

      Source sequence(s)
      AC012651
      Consensus CDS
      CCDS32208.1
      UniProtKB/Swiss-Prot
      B4DZ40, E9PE29, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H2Y7, Q9H7B8
      Related
      ENSP00000263805.4, ENST00000263805.8
      Conserved Domains (4) summary
      pfam09528
      Location:302 → 839
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG2319
      Location:1380 → 1808
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1525 → 1802
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1575 → 1614
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      42412823..42491141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432936.1 → XP_047288892.1  zinc finger protein 106 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      40218871..40297183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378612.1 → XP_054234587.1  zinc finger protein 106 isoform X1

    2. XM_054378613.1 → XP_054234588.1  zinc finger protein 106 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2Y7.1 GenPept UniProtKB/Swiss-Prot:Q9H2Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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