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    RASSF4 Ras association domain family member 4 [ Homo sapiens (human) ]

    Gene ID: 83937, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RASSF4provided by HGNC
    Official Full Name
    Ras association domain family member 4provided by HGNC
    Primary source
    HGNC:HGNC:20793
    See related
    Ensembl:ENSG00000107551 MIM:610559; AllianceGenome:HGNC:20793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD037
    Summary
    The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 36.2), fat (RPKM 31.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RASSF4 in Genome Data Viewer
    Location:
    10q11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (44959802..44995891)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45840766..45876855)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45455250..45491339)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:45304779-45305441 Neighboring gene TMEM72 antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45324635-45325498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45348956-45349456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45374502-45375428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45403886-45404386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45404387-45404887 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:45413376-45413557 Neighboring gene transmembrane protein 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45427808-45428515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45428516-45429222 Neighboring gene Sharpr-MPRA regulatory region 7362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3314 Neighboring gene Sharpr-MPRA regulatory region 11970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3317 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3318 Neighboring gene uncharacterized LOC105378281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45467973-45468635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45468636-45469297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45470934-45471637 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475153-45475856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475857-45476558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45479350-45479850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45486450-45487141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487171-45487672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487673-45488172 Neighboring gene uncharacterized LOC124902530 Neighboring gene DEPP autophagy regulator 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:45496487-45496987 Neighboring gene ZNF22 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45510141-45510640 Neighboring gene zinc finger protein 22 Neighboring gene double homeobox A pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RASSF4 is required for skeletal muscle differentiation. Lin YT, et al. Cell Biol Int, 2020 Feb. PMID 31508857, Free PMC Article
    2. Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression. De Smedt E, et al. Cancer Res, 2018 Mar 1. PMID 29259009
    3. RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells. Zhang M, et al. Oncol Res, 2017 Jan 2. PMID 28081736, Free PMC Article
    4. RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion. Han Y, et al. Tumour Biol, 2016 Apr. PMID 26526576
    5. Aberrant methylation of RASSF4/AD037 in nasopharyngeal carcinoma. Chow LS, et al. Oncol Rep, 2004 Oct. PMID 15375500

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wnt/beta-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4.
      Title: Wnt/β-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4.
    2. RASSF4 is required for skeletal muscle differentiation.
      Title: RASSF4 is required for skeletal muscle differentiation.
    3. Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.
      Title: Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.
    4. RASSF4 controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.
      Title: RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P(2).
    5. RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma cells.
      Title: RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells.
    6. the present study suggested that RASSF4 serves as an important tumor suppressor in human nonsmall cell lung cancer .
      Title: RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.
    7. RASSF4 promotes EV71 replication and the production of viral progeny to accelerate the inhibition of the phosphorylation of AKT.
      Title: RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.
    8. expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4
      Title: Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
    9. Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia.
      Title: Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC44914

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 4
    Names
    Ras association (RalGDS/AF-6) domain family 4
    Ras association (RalGDS/AF-6) domain family member 4
    Ras association domain family 4
    tumor suppressor RASSF4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032023.4 → NP_114412.2  ras association domain-containing protein 4

      See identical proteins and their annotated locations for NP_114412.2

      Status: REVIEWED

      Source sequence(s)
      AL353801, BC032593, BI601296
      Consensus CDS
      CCDS7208.1
      UniProtKB/Swiss-Prot
      Q86WH5, Q86WH6, Q86WH7, Q8N5A9, Q8TCK6, Q9H2L5
      Related
      ENSP00000339692.4, ENST00000340258.10
      Conserved Domains (1) summary
      cl00155
      Location:175 → 261
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      44959802..44995891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      45840766..45876855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178145.1: Suppressed sequence

      Description
      NM_178145.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2L5.2 GenPept UniProtKB/Swiss-Prot:Q9H2L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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