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    ELAVL4 ELAV like RNA binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 1996, updated on 3-Dec-2024

    Summary

    Official Symbol
    ELAVL4provided by HGNC
    Official Full Name
    ELAV like RNA binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:3315
    See related
    Ensembl:ENSG00000162374 MIM:168360; AllianceGenome:HGNC:3315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUD; PNEM
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and pre-mRNA intronic pyrimidine-rich binding activity. Involved in 3'-UTR-mediated mRNA stabilization; RNA processing; and positive regulation of 3'-UTR-mediated mRNA stabilization. Predicted to be located in axon; cytoplasm; and dendrite. Predicted to be part of ribonucleoprotein complex. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ELAVL4 in Genome Data Viewer
    Location:
    1p33-p32.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (50048055..50203772)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (49927008..50082746)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (50513727..50669444)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 4 Neighboring gene uncharacterized LOC105378708 Neighboring gene uncharacterized LOC105378709 Neighboring gene heart enhancer 18 Neighboring gene MT-ND2 pseudogene 29 Neighboring gene uncharacterized LOC105378711 Neighboring gene ELAVL4 antisense RNA 1 Neighboring gene uncharacterized LOC105378710 Neighboring gene MPRA-validated peak211 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:50774654-50774867 Neighboring gene long intergenic non-protein coding RNA 2808

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pre-mRNA intronic pyrimidine-rich binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation at postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ELAV-like protein 4
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
    ELAV like neuron-specific RNA binding protein 4
    Hu antigen D
    paraneoplastic encephalomyelitis antigen HuD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144774.3NP_001138246.1  ELAV-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001138246.1

      Status: VALIDATED

      Source sequence(s)
      AL592182, AY033997, BC036071, CK005107
      Consensus CDS
      CCDS44140.1
      UniProtKB/TrEMBL
      A0A494C015
      Related
      ENSP00000360889.2, ENST00000371824.7
      Conserved Domains (1) summary
      TIGR01661
      Location:43365
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    2. NM_001144775.3NP_001138247.2  ELAV-like protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001138247.2

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182, AY033996, BC036071, BM509527
      Consensus CDS
      CCDS44139.2
      UniProtKB/TrEMBL
      A0A0R4J2E6, A0A494C015
      Related
      ENSP00000349594.5, ENST00000357083.8
      Conserved Domains (1) summary
      TIGR01661
      Location:79401
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    3. NM_001144776.3NP_001138248.1  ELAV-like protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001138248.1

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182, AY033995, BC036071
      Consensus CDS
      CCDS44138.1
      UniProtKB/TrEMBL
      A0A494C015
      Related
      ENSP00000360892.1, ENST00000371827.5
      Conserved Domains (1) summary
      TIGR01661
      Location:43365
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    4. NM_001144777.3NP_001138249.1  ELAV-like protein 4 isoform 5

      See identical proteins and their annotated locations for NP_001138249.1

      Status: VALIDATED

      Source sequence(s)
      AL592182, BC036071, DC351092
      Consensus CDS
      CCDS53315.1
      UniProtKB/TrEMBL
      A0A494C015
      Related
      ENSP00000399939.2, ENST00000448907.7
      Conserved Domains (1) summary
      TIGR01661
      Location:46368
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    5. NM_001294348.2NP_001281277.1  ELAV-like protein 4 isoform 6

      See identical proteins and their annotated locations for NP_001281277.1

      Status: VALIDATED

      Source sequence(s)
      AK298902, AL592182, BC036071
      Consensus CDS
      CCDS72788.1
      UniProtKB/TrEMBL
      A0A494C015, B1APY9
      Related
      ENSP00000360884.1, ENST00000371819.1
      Conserved Domains (1) summary
      TIGR01661
      Location:48370
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    6. NM_001324208.2NP_001311137.1  ELAV-like protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182, AL645730
      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:46382
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    7. NM_001324209.2NP_001311138.1  ELAV-like protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:42351
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    8. NM_001324212.2NP_001311141.1  ELAV-like protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:42364
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    9. NM_001324213.2NP_001311142.1  ELAV-like protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Consensus CDS
      CCDS81321.1
      UniProtKB/Swiss-Prot
      B1APY6, B1APY7, B1APY8, B7Z4G7, P26378, Q8IYD4, Q96J74, Q96J75, Q9UD24
      UniProtKB/TrEMBL
      A0A494C015
      Related
      ENSP00000360886.1, ENST00000371821.6
      Conserved Domains (1) summary
      TIGR01661
      Location:48384
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    10. NM_001324214.2NP_001311143.1  ELAV-like protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      UniProtKB/TrEMBL
      A0A494C015
      Related
      ENSP00000498318.1, ENST00000651258.1
      Conserved Domains (1) summary
      TIGR01661
      Location:42364
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    11. NM_001324215.2NP_001311144.1  ELAV-like protein 4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:48357
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    12. NM_001324216.1NP_001311145.1  ELAV-like protein 4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Consensus CDS
      CCDS90949.1
      UniProtKB/TrEMBL
      A0A494C0M6, A0A494C0Q5
      Related
      ENSP00000498618.1, ENST00000652693.1
      Conserved Domains (1) summary
      cd12650
      Location:45118
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    13. NM_001324217.2NP_001311146.1  ELAV-like protein 4 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      UniProtKB/TrEMBL
      A0A494C0Q5
      Conserved Domains (1) summary
      cd12650
      Location:50123
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    14. NM_001410787.1NP_001397716.1  ELAV-like protein 4 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Consensus CDS
      CCDS90950.1
      UniProtKB/TrEMBL
      A0A494C015, A0A494C1D9
      Related
      ENSP00000498979.1, ENST00000650764.1
    15. NM_021952.5NP_068771.2  ELAV-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_068771.2

      Status: VALIDATED

      Source sequence(s)
      AL592182, AY033998, BC036071, CK005107
      Consensus CDS
      CCDS553.1
      UniProtKB/TrEMBL
      A0A494C015
      Related
      ENSP00000360888.4, ENST00000371823.8
      Conserved Domains (1) summary
      TIGR01661
      Location:43379
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RNA

    1. NR_136725.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      50048055..50203772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000542.1XP_016856031.1  ELAV-like protein 4 isoform X11

      UniProtKB/TrEMBL
      A0A494C0Q5
      Conserved Domains (1) summary
      cd12650
      Location:48121
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    2. XM_011540893.3XP_011539195.1  ELAV-like protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011539195.1

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (4) summary
      cd12650
      Location:45122
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:294379
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:43379
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:127216
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_047448337.1XP_047304293.1  ELAV-like protein 4 isoform X12

      UniProtKB/TrEMBL
      A0A494C0Q5
      Related
      ENST00000492299.2
    4. XM_006710411.4XP_006710474.1  ELAV-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006710474.1

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:56392
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    5. XM_017000538.1XP_016856027.1  ELAV-like protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A494C015, A0A494C147
      Related
      ENSP00000498865.1, ENST00000651347.1
      Conserved Domains (4) summary
      cd12650
      Location:58135
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:293378
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:56378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:140229
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_017000541.2XP_016856030.1  ELAV-like protein 4 isoform X10

    7. XM_011540889.4XP_011539191.1  ELAV-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011539191.1

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:79415
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    8. XM_011540890.3XP_011539192.1  ELAV-like protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011539192.1

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:79388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    9. XM_017000540.2XP_016856029.1  ELAV-like protein 4 isoform X9

      Conserved Domains (1) summary
      TIGR01661
      Location:79156
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    10. XM_011540895.4XP_011539197.1  ELAV-like protein 4 isoform X6

      See identical proteins and their annotated locations for XP_011539197.1

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:42378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    11. XM_011540894.3XP_011539196.1  ELAV-like protein 4 isoform X6

      See identical proteins and their annotated locations for XP_011539196.1

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:42378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    12. XM_024453822.2XP_024309590.1  ELAV-like protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:55377
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    13. XM_024453825.1XP_024309593.1  ELAV-like protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A494C015
      Conserved Domains (1) summary
      TIGR01661
      Location:42364
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      49927008..50082746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334873.1XP_054190848.1  ELAV-like protein 4 isoform X11

      UniProtKB/TrEMBL
      A0A494C0Q5
    2. XM_054334865.1XP_054190840.1  ELAV-like protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A494C015
    3. XM_054334874.1XP_054190849.1  ELAV-like protein 4 isoform X12

      UniProtKB/TrEMBL
      A0A494C0Q5
    4. XM_054334872.1XP_054190847.1  ELAV-like protein 4 isoform X10

    5. XM_054334867.1XP_054190842.1  ELAV-like protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A494C015, A0A494C147
    6. XM_054334863.1XP_054190838.1  ELAV-like protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A494C015
    7. XM_054334862.1XP_054190837.1  ELAV-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A494C015
    8. XM_054334864.1XP_054190839.1  ELAV-like protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A494C015
    9. XM_054334871.1XP_054190846.1  ELAV-like protein 4 isoform X9

    10. XM_054334866.1XP_054190841.1  ELAV-like protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A494C015
    11. XM_054334868.1XP_054190843.1  ELAV-like protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A494C015
    12. XM_054334869.1XP_054190844.1  ELAV-like protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A494C015
    13. XM_054334870.1XP_054190845.1  ELAV-like protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A494C015