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    HACD3 3-hydroxyacyl-CoA dehydratase 3 [ Homo sapiens (human) ]

    Gene ID: 51495, updated on 10-Dec-2024

    Summary

    Official Symbol
    HACD3provided by HGNC
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 3provided by HGNC
    Primary source
    HGNC:HGNC:24175
    See related
    Ensembl:ENSG00000074696 MIM:615940; AllianceGenome:HGNC:24175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIND1; B-IND1; HSPC121; PTPLAD1
    Summary
    Enables enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Involved in fatty acid biosynthetic process; positive regulation by virus of viral protein levels in host cell; and positive regulation of viral genome replication. Located in endoplasmic reticulum and nuclear membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 49.9), adrenal (RPKM 46.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See HACD3 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65530463..65578349)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63339879..63387748)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65822801..65870687)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily DCC subclass member 4 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65707062-65707929 Neighboring gene uncharacterized LOC124903510 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:65710136-65710346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9600 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:65715563-65716097 Neighboring gene dipeptidyl peptidase 8 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65809274-65809827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65821125-65821625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6556 Neighboring gene MPRA-validated peak2372 silencer Neighboring gene RNA, U6 small nuclear 19, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr15:65871212-65871790 Neighboring gene integrator complex subunit 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9602 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:65910767-65911352 Neighboring gene uncharacterized LOC102723464 Neighboring gene solute carrier family 24 member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ90376

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum membrane  
    located_in focal adhesion PubMed 
    located_in nuclear membrane  

    General protein information

    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
    Names
    butyrate-induced protein 1
    butyrate-induced transcript 1
    protein tyrosine phosphatase-like A domain containing 1
    protein tyrosine phosphatase-like protein PTPLAD1
    protein-tyrosine phosphatase-like A domain-containing protein 1
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
    NP_001398065.1
    NP_057479.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411136.1 → NP_001398065.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC011846, AC027220
      Consensus CDS
      CCDS92019.1
      UniProtKB/TrEMBL
      H3BRL8
      Related
      ENSP00000456300.1, ENST00000566074.5
    2. NM_016395.4 → NP_057479.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 1

      See identical proteins and their annotated locations for NP_057479.2

      Status: VALIDATED

      Source sequence(s)
      AC011846, AC027220
      Consensus CDS
      CCDS45282.1
      UniProtKB/Swiss-Prot
      A0PJA1, B4DRF4, Q280Z3, Q6PD63, Q8IUI5, Q8NC86, Q8NCB1, Q96T12, Q9NQA7, Q9P035
      UniProtKB/TrEMBL
      H3BPZ1
      Related
      ENSP00000261875.5, ENST00000261875.10
      Conserved Domains (2) summary
      cd06465
      Location:8 → 115
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
      pfam04387
      Location:195 → 355
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      65530463..65578349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      63339879..63387748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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