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    Anxa4 annexin A4 [ Mus musculus (house mouse) ]

    Gene ID: 11746, updated on 13-Jan-2025

    Summary

    Official Symbol
    Anxa4provided by MGI
    Official Full Name
    annexin A4provided by MGI
    Primary source
    MGI:MGI:88030
    See related
    Ensembl:ENSMUSG00000029994 AllianceGenome:MGI:88030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIV; Anx4; Xanx-4
    Summary
    Predicted to enable several functions, including NF-kappaB binding activity; calcium-dependent protein binding activity; and phospholipid binding activity. Acts upstream of or within Notch signaling pathway. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; chordamesoderm; inner ear; and lung. Orthologous to human ANXA4 (annexin A4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in large intestine adult (RPKM 135.1), small intestine adult (RPKM 70.5) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Anxa4 in Genome Data Viewer
    Location:
    6 D1; 6 37.75 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86713822..86770616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86736840..86793634, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86634487-86634670 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5) Neighboring gene germ cell-less, spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene NFU1 iron-sulfur cluster scaffold

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding  
    enables NF-kappaB binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent protein binding  
    enables calcium-dependent protein binding  
    enables identical protein binding  
    enables identical protein binding  
    enables phosphatidylserine binding  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nuclear membrane  
    located_in nuclear membrane  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in vesicle membrane  
    located_in vesicle membrane  
    located_in zymogen granule membrane  

    General protein information

    Preferred Names
    annexin A4
    Names
    annexin IV
    annexin-4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331120.1NP_001318049.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662, AK132293, AK150486
      Consensus CDS
      CCDS39543.1
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Conserved Domains (1) summary
      pfam00191
      Location:249314
      Annexin
    2. NM_001409435.1NP_001396364.1  annexin A4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/TrEMBL
      Q7TMN7
    3. NM_001409436.1NP_001396365.1  annexin A4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      Q7TMN7
    4. NM_001409437.1NP_001396366.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000145421.2, ENSMUST00000204441.3
    5. NM_001409438.1NP_001396367.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
    6. NM_001409439.1NP_001396368.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000144961.2, ENSMUST00000204398.2
    7. NM_001409442.1NP_001396371.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000109305.2, ENSMUST00000113675.8
    8. NM_001409443.1NP_001396372.1  annexin A4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/TrEMBL
      D3Z0S1
      Related
      ENSMUSP00000115346.2, ENSMUST00000123732.4
    9. NM_001409444.1NP_001396373.1  annexin A4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      Q7TMN7
    10. NM_001409445.1NP_001396374.1  annexin A4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/TrEMBL
      A0A0N4SV57, Q8BSL2
    11. NM_001409446.1NP_001396375.1  annexin A4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      A0A0N4SV57, Q8BSL2
      Related
      ENSMUST00000129772.2
    12. NM_001409447.1NP_001396376.1  annexin A4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      Q9R0V2
    13. NM_001409448.1NP_001396377.1  annexin A4 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
    14. NM_013471.3NP_038499.2  annexin A4 isoform a

      See identical proteins and their annotated locations for NP_038499.2

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      Consensus CDS
      CCDS39543.1
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000001187.9, ENSMUST00000001187.15
      Conserved Domains (1) summary
      pfam00191
      Location:249314
      Annexin

    RNA

    1. NR_176838.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158662

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86713822..86770616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165761.1XP_036021654.1  annexin A4 isoform X1

      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Conserved Domains (1) summary
      pfam00191
      Location:249314
      Annexin
    2. XM_011241158.3XP_011239460.1  annexin A4 isoform X2

      UniProtKB/TrEMBL
      Q9R0V2, S4R1F2
      Related
      ENSMUSP00000138194.2, ENSMUST00000127152.9
      Conserved Domains (1) summary
      pfam00191
      Location:90155
      Annexin

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