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    Nodal nodal growth differentiation factor [ Mus musculus (house mouse) ]

    Gene ID: 18119, updated on 14-Jan-2025

    Summary

    Official Symbol
    Nodalprovided by MGI
    Official Full Name
    nodal growth differentiation factorprovided by MGI
    Primary source
    MGI:MGI:97359
    See related
    Ensembl:ENSMUSG00000037171 AllianceGenome:MGI:97359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tg.413d
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Nodal in Genome Data Viewer
    Location:
    10 B4; 10 32.21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61253751..61261117)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61417972..61425338)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_26836 Neighboring gene phosphatase domain containing, paladin 1 Neighboring gene STARR-seq mESC enhancer starr_26839 Neighboring gene STARR-seq mESC enhancer starr_26844 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3888 Neighboring gene STARR-seq mESC enhancer starr_26847 Neighboring gene RIKEN cDNA D830039M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6860 Neighboring gene leucine rich repeat containing 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables protein binding PubMed 
    enables receptor ligand activity PubMed 
    enables type I activin receptor binding  
    enables type I activin receptor binding  
    Items 1 - 25 of 90
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis PubMed 
    acts_upstream_of_or_within anterior/posterior axis specification PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within axial mesodermal cell fate specification PubMed 
    acts_upstream_of_or_within brain development PubMed 
    acts_upstream_of cell differentiation PubMed 
    acts_upstream_of_or_within cell fate commitment PubMed 
    acts_upstream_of_or_within cell migration PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in determination of left/right asymmetry in lateral mesoderm PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    involved_in determination of left/right symmetry PubMed 
    acts_upstream_of_or_within digestive system development PubMed 
    acts_upstream_of_or_within digestive tract morphogenesis PubMed 
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis PubMed 
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    acts_upstream_of_or_within embryonic pattern specification PubMed 
    acts_upstream_of_or_within embryonic placenta development PubMed 
    acts_upstream_of_or_within embryonic process involved in female pregnancy PubMed 
    acts_upstream_of_or_within endoderm development PubMed 
    involved_in endodermal cell differentiation  
    involved_in endodermal cell differentiation  
    acts_upstream_of_or_within epiblast cell-extraembryonic ectoderm cell signaling PubMed 
    acts_upstream_of_or_within floor plate morphogenesis PubMed 
    acts_upstream_of_or_within formation of anatomical boundary PubMed 
    acts_upstream_of_or_within gastrulation PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second PubMed 
    acts_upstream_of germ cell development PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within heart looping PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation PubMed 
    acts_upstream_of_or_within left lung morphogenesis PubMed 
    acts_upstream_of_or_within liver development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within maternal placenta development PubMed 
    acts_upstream_of_or_within maternal process involved in parturition PubMed 
    acts_upstream_of_or_within mesendoderm development PubMed 
    involved_in mesendoderm development  
    acts_upstream_of_or_within mesoderm formation PubMed 
    involved_in mesoderm formation PubMed 
    involved_in negative regulation of androgen receptor signaling pathway  
    involved_in negative regulation of androgen receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of cell development PubMed 
    acts_upstream_of_or_within negative regulation of cell differentiation PubMed 
    involved_in negative regulation of chorionic trophoblast cell proliferation  
    involved_in negative regulation of chorionic trophoblast cell proliferation  
    acts_upstream_of_or_within negative regulation of reproductive process PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of trophoblast cell migration  
    involved_in negative regulation of trophoblast cell migration  
    acts_upstream_of_or_within nervous system development PubMed 
    acts_upstream_of_or_within neural fold formation PubMed 
    involved_in nodal signaling pathway PubMed 
    involved_in placenta development  
    acts_upstream_of_or_within polarity specification of proximal/distal axis PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell-cell adhesion  
    involved_in positive regulation of cell-cell adhesion  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of vascular endothelial growth factor production  
    involved_in positive regulation of vascular endothelial growth factor production  
    acts_upstream_of_or_within primitive streak formation PubMed 
    acts_upstream_of_or_within regulation of gastrulation PubMed 
    acts_upstream_of_or_within regulation of signal transduction PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    acts_upstream_of_or_within stem cell population maintenance PubMed 
    acts_upstream_of_or_within tissue morphogenesis PubMed 
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of_or_within trophectodermal cell differentiation PubMed 
    acts_upstream_of_or_within trophectodermal cellular morphogenesis PubMed 
    acts_upstream_of_or_within vasculature development PubMed 
    Items 1 - 25 of 90
    Component Evidence Code Pubs
    located_in extracellular region PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013611.5NP_038639.2  nodal preproprotein

      See identical proteins and their annotated locations for NP_038639.2

      Status: REVIEWED

      Source sequence(s)
      AC122197, AK049290
      Consensus CDS
      CCDS23878.1
      UniProtKB/Swiss-Prot
      P43021, Q8BH87
      UniProtKB/TrEMBL
      A0PK81
      Related
      ENSMUSP00000039653.6, ENSMUST00000049339.7
      Conserved Domains (2) summary
      smart00204
      Location:254353
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:33169
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61253751..61261117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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