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    Gulp1 GULP, engulfment adaptor PTB domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70676, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gulp1provided by MGI
    Official Full Name
    GULP, engulfment adaptor PTB domain containing 1provided by MGI
    Primary source
    MGI:MGI:1920407
    See related
    Ensembl:ENSMUSG00000056870 AllianceGenome:MGI:1920407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ced6; GULP; CED-6; Gulp-2; 3110030A04Rik; 5730529O06Rik
    Summary
    Predicted to be involved in apoptotic process and lipid transport. Predicted to act upstream of or within phagocytosis, engulfment. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in limb E14.5 (RPKM 12.2), bladder adult (RPKM 6.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gulp1 in Genome Data Viewer
    Location:
    1 C1.1; 1 23.63 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (44590540..44835998)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (44551380..44796838)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00802 Neighboring gene STARR-seq mESC enhancer starr_00803 Neighboring gene STARR-seq mESC enhancer starr_00804 Neighboring gene predicted gene 28893 Neighboring gene thioredoxin, pseudogene 1 Neighboring gene predicted gene, 39635 Neighboring gene STARR-seq mESC enhancer starr_00806 Neighboring gene STARR-seq mESC enhancer starr_00807 Neighboring gene STARR-seq mESC enhancer starr_00808 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene RIKEN cDNA 4930521E06 gene Neighboring gene STARR-seq mESC enhancer starr_00809 Neighboring gene predicted gene 3489 Neighboring gene predicted gene, 19480

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF-β/SMAD2/3 pathway. Kim D, et al. FEBS Lett, 2024 Apr. PMID 38553249
    2. GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells. Kim SY, et al. J Cell Physiol, 2024 Feb. PMID 38214103
    3. Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17β-estradiol levels. Kim SY, et al. J Cell Physiol, 2023 May. PMID 36870066
    4. Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans. Banerjee H, et al. Plasmid, 2003 Jan. PMID 12583998
    5. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Sullivan CS, et al. Mol Biol Cell, 2014 Jun 15. PMID 24743597, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans.
      Title: CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans.
    2. Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF-beta/SMAD2/3 pathway.
      Title: Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF-β/SMAD2/3 pathway.
    3. GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells.
      Title: GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells.
    4. Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17beta-estradiol levels.
      Title: Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17β-estradiol levels.
    5. Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism.
      Title: The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.
    6. Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton.
      Title: Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.
    7. in this study we report the identification of a novel C. elegans CED-6-like orthologue in mouse, which has probable apoptotic like function
      Title: Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PTB domain-containing engulfment adapter protein 1
    Names
    CED 6
    PTB domain adapter protein CED-6
    cell death protein 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028450.3 → NP_082726.2  PTB domain-containing engulfment adapter protein 1

      Status: VALIDATED

      Source sequence(s)
      AK036670, BE632215, BY713087
      Consensus CDS
      CCDS48250.1
      UniProtKB/Swiss-Prot
      Q8K2A1, Q9CRV4, Q9CYD2
      UniProtKB/TrEMBL
      Q0PNF0
      Related
      ENSMUSP00000074115.4, ENSMUST00000074525.10
      Conserved Domains (3) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam04880
      Location:167 → 258
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam10211
      Location:135 → 198
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      44590540..44835998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496277.4 → XP_006496340.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/TrEMBL
      E0CXC5, Q0PNF0
      Related
      ENSMUSP00000124756.2, ENSMUST00000162600.2
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:136 → 206
      Ax_dynein_light; Axonemal dynein light chain

    2. XM_006496276.4 → XP_006496339.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      Q0PNF0
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:136 → 206
      Ax_dynein_light; Axonemal dynein light chain

    3. XM_006496278.4 → XP_006496341.1  PTB domain-containing engulfment adapter protein 1 isoform X3

      UniProtKB/TrEMBL
      Q0PNF0
      Conserved Domains (3) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam04880
      Location:167 → 246
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam10211
      Location:136 → 198
      Ax_dynein_light; Axonemal dynein light chain

    4. XM_011238599.3 → XP_011236901.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      Q0PNF0
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:136 → 206
      Ax_dynein_light; Axonemal dynein light chain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027506.2: Suppressed sequence

      Description
      NM_027506.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2A1.1 GenPept UniProtKB/Swiss-Prot:Q8K2A1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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