C1h6orf120 similar to human chromosome 6 open reading frame 120 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1h6orf120provided by RGD
Official Full Name: similar to human chromosome 6 open reading frame 120provided by RGD
Primary source: RGD:1642424
See related: EnsemblRapid:ENSRNOG00000070184 AllianceGenome:RGD:1642424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C6orf120
Summary: Predicted to be involved in apoptotic process. Predicted to be located in extracellular region. Orthologous to human C6orf120 (chromosome 6 open reading frame 120). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 93.9), Liver (RPKM 89.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (64623569..64626291)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (55950449..55953173)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (56949712..56952436)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway.
Title: Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway.
C6orf120 gene knockout in rats mitigates concanavalin Ainduced autoimmune hepatitis via regulating NKT cells.
Title: C6orf120 gene knockout in rats mitigates concanavalin A‑induced autoimmune hepatitis via regulating NKT cells.

Submit: New GeneRIF Correction

General gene information

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Markers

d1rat256 (e-PCR)
- UniSTS:121484

RH132671 (e-PCR)
- UniSTS:215954

RH130186 (e-PCR)
- UniSTS:213473

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UPF0669 protein C6orf120 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.