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    Eif4g1 eukaryotic translation initiation factor 4 gamma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287986, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eif4g1provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4 gamma 1provided by RGD
    Primary source
    RGD:1306144
    See related
    EnsemblRapid:ENSRNOG00000001738 AllianceGenome:RGD:1306144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables eukaryotic initiation factor 4E binding activity. Involved in lung development and response to ethanol. Part of eukaryotic translation initiation factor 4F complex. Is active in postsynapse. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 862.7), Heart (RPKM 764.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4g1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93726322..93746387, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80221919..80241958, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83907659..83927683, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene chloride voltage-gated channel 2 Neighboring gene family with sequence similarity 131, member A Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Neighboring gene uncharacterized LOC102551589 Neighboring gene endothelin-converting enzyme 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dendritic BC1 RNA: functional role in regulation of translation initiation. Wang H, et al. J Neurosci, 2002 Dec 1. PMID 12451124, Free PMC Article
    2. Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis. Vary TC, et al. Shock, 2006 Dec. PMID 17117141
    3. Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex. Akabayov SR, et al. Biochemistry, 2014 Oct 21. PMID 25255371, Free PMC Article
    4. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Hoeffer CA, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21289279, Free PMC Article
    5. Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Bellsolell L, et al. Structure, 2006 May. PMID 16698552

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate that calpain-mediated degradation of a translation initiation factor, eIF4G1, is a cause of both persistent PSI and neuronal death
      Title: Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.
    2. At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption.
      Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
    3. the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial learning than for that triggered by reactivation of an existing memory.
      Title: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.
    4. eIF4E-eIF4G association and phosphorylation of 4E-BP1 and GSK-3 are increased after HFES in adult, but not in aged, animals.
      Title: Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle.
    5. IL-1 is the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G
      Title: Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic initiation factor 4E binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lung development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4 gamma 1
    Names
    eukaryotic translation initiation factor 4 gamma 1-like
    voltage-dependent P/Q-type calcium channel subunit alpha-1A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427476.1 → NP_001414405.1  eukaryotic translation initiation factor 4 gamma 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      93726322..93746387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270353.1 → XP_063126423.1  eukaryotic translation initiation factor 4 gamma 1 isoform X14

    2. XM_063270352.1 → XP_063126422.1  eukaryotic translation initiation factor 4 gamma 1 isoform X13

    3. XM_063270350.1 → XP_063126420.1  eukaryotic translation initiation factor 4 gamma 1 isoform X12

    4. XM_063270348.1 → XP_063126418.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

    5. XM_063270346.1 → XP_063126416.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

    6. XM_063270343.1 → XP_063126413.1  eukaryotic translation initiation factor 4 gamma 1 isoform X8

    7. XM_006248584.5 → XP_006248646.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

      See identical proteins and their annotated locations for XP_006248646.1

      UniProtKB/TrEMBL
      D4AD15
      Related
      ENSRNOP00000040698.6, ENSRNOT00000040029.7
      Conserved Domains (3) summary
      cd11559
      Location:1433 → 1562
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1234 → 1346
      MA3; MA3 domain
      pfam02854
      Location:757 → 985
      MIF4G; MIF4G domain

    8. XM_063270355.1 → XP_063126425.1  eukaryotic translation initiation factor 4 gamma 1 isoform X15

    9. XM_063270347.1 → XP_063126417.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

    10. XM_063270344.1 → XP_063126414.1  eukaryotic translation initiation factor 4 gamma 1 isoform X8

    11. XM_063270354.1 → XP_063126424.1  eukaryotic translation initiation factor 4 gamma 1 isoform X14

    12. XM_063270351.1 → XP_063126421.1  eukaryotic translation initiation factor 4 gamma 1 isoform X13

    13. XM_063270340.1 → XP_063126410.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

    14. XM_006248585.5 → XP_006248647.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

      See identical proteins and their annotated locations for XP_006248647.1

      UniProtKB/TrEMBL
      D4AD15
      Conserved Domains (3) summary
      cd11559
      Location:1433 → 1562
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1234 → 1346
      MA3; MA3 domain
      pfam02854
      Location:757 → 985
      MIF4G; MIF4G domain

    15. XM_006248581.5 → XP_006248643.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      See identical proteins and their annotated locations for XP_006248643.1

      UniProtKB/TrEMBL
      M0RD03
      Conserved Domains (3) summary
      cd11559
      Location:1440 → 1569
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1241 → 1353
      MA3; MA3 domain
      pfam02854
      Location:764 → 992
      MIF4G; MIF4G domain

    16. XM_017598182.3 → XP_017453671.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      UniProtKB/TrEMBL
      M0RD03
      Related
      ENSRNOP00000049629.4, ENSRNOT00000041777.8
      Conserved Domains (3) summary
      cd11559
      Location:1440 → 1569
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1241 → 1353
      MA3; MA3 domain
      pfam02854
      Location:764 → 992
      MIF4G; MIF4G domain

    17. XM_063270341.1 → XP_063126411.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

    18. XM_063270339.1 → XP_063126409.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

    19. XM_063270349.1 → XP_063126419.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

    20. XM_063270345.1 → XP_063126415.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

    21. XM_063270342.1 → XP_063126412.1  eukaryotic translation initiation factor 4 gamma 1 isoform X7

    22. XM_063270338.1 → XP_063126408.1  eukaryotic translation initiation factor 4 gamma 1 isoform X4

    23. XM_063270336.1 → XP_063126406.1  eukaryotic translation initiation factor 4 gamma 1 isoform X2

      UniProtKB/TrEMBL
      D3ZU13

    24. XM_063270337.1 → XP_063126407.1  eukaryotic translation initiation factor 4 gamma 1 isoform X3

    25. XM_017598183.2 → XP_017453672.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      UniProtKB/TrEMBL
      M0RD03
      Conserved Domains (3) summary
      cd11559
      Location:1440 → 1569
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1241 → 1353
      MA3; MA3 domain
      pfam02854
      Location:764 → 992
      MIF4G; MIF4G domain

    26. XM_063270358.1 → XP_063126428.1  eukaryotic translation initiation factor 4 gamma 1 isoform X18

    27. XM_063270360.1 → XP_063126430.1  eukaryotic translation initiation factor 4 gamma 1 isoform X19

    28. XM_063270356.1 → XP_063126426.1  eukaryotic translation initiation factor 4 gamma 1 isoform X16

    29. XM_063270357.1 → XP_063126427.1  eukaryotic translation initiation factor 4 gamma 1 isoform X17

    Nucleotide Protein Strain
    Heading Accession and Version

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